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The collection consists of approximately 100 items on alchemy and early chemistry, the most notable item being De Secretis Mulierum. The collection also includes manuscripts of lectures given by Sir Henry Roscoe; his notes on solar chemistry work; letters written to him by a number of his peers and his notebook from 1849. The many volumes of letters in the collection includes correspondence with contemporaries such as Robert Bunsen, Michael Faraday, Dmitri Mendeleeff and Louis Pasteur as well as with a number of Presidents of the Chemical Society and the Royal Institute of Chemistry.