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The collection is divided into four main groups: The first group contains papers relating to William Clift's work as conservator of the Hunterian Museum. This is the largest of the four groups and contains a number of sub divisions such as explanation and display of specimens, expanding the collections, administration of the museum, and correspondence. This group also contains the transcripts made by Clift and others of the Hunterian manuscripts. The second group contains work carried out by William Clift as an illustrator for publications. The third group contains a small amount of personal material that is in the collection. The fourth group contains transcripts and copies of manuscript material by William Clift that is held in other repositories such as the Natural History Museum.

The papers contain Keith's extensive correspondence, diaries (1908-1954), reports on work as conservator annual (1931-1934) and quarterly reports (1928-1932), talks, drafts of publications, unpublished manuscripts; drawings, notes on visits to Siam, Egypt and America.

Records of the Royal Polytechnic Institution (RPI), 1837-1881 and undated, comprising:

Leases of premises, 1838-1876, including no 5 Cavendish Square; prospectus, 1837; correspondence and papers concerning the foundation of the Institution, its provisional committee, shares, status and affairs, 1837-1839 and undated, including its charter, 1839, and papers on arbitration on a dispute between W M Nurse and the Institution; correspondence and papers relating to activities and affairs of the Institution, 1838-1842 and undated, including documents on the alleged infringement by the Institution of a patent for a diving dress, 1838, and an agreement with W H F Talbot permitting the use of his patented photographic process, 1841; photocopy of a letter from Robert Longbottom, RPI Secretary, to Samuel Morse, 1846; copy of charter, 1852; letter concerning a school visit to the RPI, 1858;

Catalogues of the Polytechnic Institution (copies), 1838-1840, and Royal Polytechnic Institution, 1844-1845; programmes for 1861, 1876, 1878 and 1881; bound volumes of RPI programmes, 1873-1878; reports, 1879-1880; particulars and conditions of sale of the RPI premises, 1881;

Books by authors associated with the RPI, including various publications by John Henry Pepper: The Boy's Playbook of Science, 2nd edition, 1860.; Popular Lectures for Young People and Half Hours with the Alchemists, 1st edition, 1855; The Playbook of Metals, 1st edition, 1869 and Cyclopaedic Science Simplified, 1st edition, 1869; The Book of The Lantern by T C Hepworth, 2nd edition, 1889; Memory by William Stokes, 2nd edition, 1888 and Rapid Writing by William Stokes, 4th edition, 1873; issues of various contemporary journals containing information on or advertisements for the Institution [1839]-1845, some with illustrations, among them scientific equipment, including four parts of the London Polytechnic Magazine, 1844, six parts of its continuation, The Polytechnic Review and Magazine, 1844, and five parts, 1845; advertising poster, 1840;

Book of press cuttings relating to the Institution from 1842, many lacking details of their source; five tokens bearing the name of the Institution, 1840; photogenic transfer made at the Institution, 1840; a ceramic plate fired at the RPI, 1866;

Illustrations and photographs of illustrations from 1840, some undated, including the great hall and other shots of the interior and exterior, 1843, and demonstrations, including the diving bell.