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Papers of Daniel Whistler, including commonplace books of prescriptions, diagnoses, exercises in metaphysics and logic, philology, definitions of terms, notes on heraldry and extracts from Aristotle and Hippocrates (in Greek) and from Mercurialis, Fernelius, Sennentus, and others (in Latin); extracts from Tacitus, Caesar, Suetonius, Plutarch, Strabo, Pliny, Quintilian, Aeschylus and Valerius Maximus, in the hand of Whistler; In Aristotelis lib.3 Physicorum Commentarius Analyticus in the hand of Whistler; cash book, pharmacopoeia and medical aphorisms.

The Brain archive comprises his personal and professional papers together with sampled case notes from his private practice, 1865-1977. As well as medical papers, there is a significant amount of material relating to Brain's philosophical and literary interests, and some papers of Brain's family and of his wife Stella (nee Langdon-Down).