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The collection is divided into four main groups: The first group contains papers relating to William Clift's work as conservator of the Hunterian Museum. This is the largest of the four groups and contains a number of sub divisions such as explanation and display of specimens, expanding the collections, administration of the museum, and correspondence. This group also contains the transcripts made by Clift and others of the Hunterian manuscripts. The second group contains work carried out by William Clift as an illustrator for publications. The third group contains a small amount of personal material that is in the collection. The fourth group contains transcripts and copies of manuscript material by William Clift that is held in other repositories such as the Natural History Museum.

Papers of Sir William Henry Flower, [1845-1883], comprising papers largely created and compiled as Curator of the Hunterian Museum of the Royal College of Surgeons of England, relating to a collection of birds' eggs, undated; rough list of contents of store bottles, undated; payments for expenses on specimens for the Museum during 1802-1861, 1861; list of additions purchased for the Museum during 1806-1862, [c1862]; summary of principal duties and occupations of museum officers and servants in the absence of the Conservator, undated; salaries and wages for the museum department, 1861; list of specimens presented by Dr Andrew Murray, 1865; list of specimens presented to the Museum by W L Crowther, [1868]; report on the Hunterian documents held by the Royal College of Surgeons of England, 1868; report on the state of the physiological series in the museum, 1869; description of pathological specimens from the bodies of soldiers who died insane, forwarded by Dr William Julius Mickle, 1876; list of preparations from the College Collection, 1876; list of total numbers of preparations in the Museum, 1877.

papers relating to preparations of specimens, duties of Royal College of Surgeons of England, museum staff; catalogues of physiological and pathological specimens; letter to Alban Doran; correspondence with Thomas Stone; correspondence with Edward Shuter, 1845-1883.