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The collection is divided into four main groups: The first group contains papers relating to William Clift's work as conservator of the Hunterian Museum. This is the largest of the four groups and contains a number of sub divisions such as explanation and display of specimens, expanding the collections, administration of the museum, and correspondence. This group also contains the transcripts made by Clift and others of the Hunterian manuscripts. The second group contains work carried out by William Clift as an illustrator for publications. The third group contains a small amount of personal material that is in the collection. The fourth group contains transcripts and copies of manuscript material by William Clift that is held in other repositories such as the Natural History Museum.

Papers of Sir William Henry Flower, [1845-1883], comprising papers largely created and compiled as Curator of the Hunterian Museum of the Royal College of Surgeons of England, relating to a collection of birds' eggs, undated; rough list of contents of store bottles, undated; payments for expenses on specimens for the Museum during 1802-1861, 1861; list of additions purchased for the Museum during 1806-1862, [c1862]; summary of principal duties and occupations of museum officers and servants in the absence of the Conservator, undated; salaries and wages for the museum department, 1861; list of specimens presented by Dr Andrew Murray, 1865; list of specimens presented to the Museum by W L Crowther, [1868]; report on the Hunterian documents held by the Royal College of Surgeons of England, 1868; report on the state of the physiological series in the museum, 1869; description of pathological specimens from the bodies of soldiers who died insane, forwarded by Dr William Julius Mickle, 1876; list of preparations from the College Collection, 1876; list of total numbers of preparations in the Museum, 1877.

papers relating to preparations of specimens, duties of Royal College of Surgeons of England, museum staff; catalogues of physiological and pathological specimens; letter to Alban Doran; correspondence with Thomas Stone; correspondence with Edward Shuter, 1845-1883.

Papers of Sir Richard Owen, [1831-1873], comprising papers relating to his scientific research and as Curator of the Hunterian Museum of the Royal College of Surgeons of England.

Papers largely relating to Owens' research and publications, including work on specimens of the Hunterian Museum and other institutions, namely original illustrations for plates published in his works and proof sheets; notes of dissections performed at the Zoological Society; report of preparations in comparative anatomy from animals which have died at the Zoological Gardens, 1831; report on the dugong received by the Zoological Society, 1831; paper on metamorphosis of insects; notes and sketch on python and boa; papers relating to a variety of subjects, including temporal mastoid-mammals; viscera and muscles of the myrmecophaga jubata (anteater); distinction of an animal from a vegetable; animal kingdom; order ophidia; serpents from British Fossil Reptiles, [c1850s]; list of 'Mr Cumming's Mollusca'; notes on birds closest in structure to mammalia; classified list of D Bennet esq's specimens of natural history, [1836]; notes on the hyoid, with sketches on the salamander; illustrations of cetacea; notes on the fore-foot, megatherium (giant sloth); loose notes on generation; notes on homologies; plates and notes on histology of animals; description of a malformed foetal heart; notes on composition of vertebral segments; notes on the dermo-skeleton, operculum and of a lecture on digestion; notes on belemites; memoranda on various subjects, including harpa ventricosa and Ehrenberg's classification with letters from naturalists; description of the skeleton of an extinct gigantic sloth, [c1842], and megatherium; report of preparations in comparative anatomy from animals which have died at the Zoological Gardens; report on the dugong received by the Zoological Society, 1831; notes on the giraffe, 1837; notes and sketches on a dugong, 1838; notes on the incubation and development of the chick; notes and plates on odontography, 1844; printed papers on Dinornis maximus (moa), with annotations by Owen, 1848-1851; memoir of William Clift, [c1850]; report on the dissection of the chimpanzee, 1844; notes taken at the Garden of Plants, Paris, 1847;

papers largely relating to the administration of the museum collection, namely lists of specimens, additions to the collection from other collections and reports to the Board of Curators of the Museum, including list of Hunterian documents handed by Owen to the Museum Committee; list of duplicate specimens in the College; selection from the collection of M Verraux; report to the Board of Curators, 1833; report on the present state of the museum, 1833; list of second selection of specimens from Mr Langstaff's collection, 1835; list of preparations in spirit presented by F D Bennett, 1836; donations from the Army Medical Departments; donations since July [1843]; report on duties of officers and servants of the Museum, 1852; plans for additional museum space, 1831; report to the Board of Curators on the Museum of Comparative Anatomy in the Garden of Plants, Paris, 1831; observations on the state of the College Museum, 1833; general account of specimens of comparative anatomy and natural history presented to the Museum by George Bennett, 1834; list of specimens proposed to be transferred to the British Museum and specimens of osteology proposed in place of the transfers, 1833-1834; report to the Committee on the chimpanzee, and copies of related correspondence, 1840; report on the physiological catalogue, 1840; list of duplicate preparations from the museum of Sir Astley Cooper not desirable for the College Museum, 1843; list of specimens selected for the College from Dr Buckland's series of bones of dinornis, 1844; report on additional space required for the collection, 1845; list of osteological specimens purchased at Steven's Auction Room, 1847; list of donations from Sir Thomas W Wilson, 1852;

papers relating to catalogues of the Hunterian Museum, including sketches and notes for an osteological catalogue, [?1840s]; notes and classifications referring to specimens in the Museum, [1827-1856]; Catalogue of Hunterian Osteological specimens, [?1853]; notes made whilst producing the catalogue of comparative anatomy, ?1831; printed histological catalogue of the Museum, with annotations, 1850; papers prepared for publication of descriptive catalogue of the fossil organic remains of invertebrata in the museum, 1856;

papers relating to the Hunterian lectures delivered by Owen at the College, including museum lectures on the animal kingdom, (Owen's first course of Museum lectures) c1837; notes for lectures delivered at the Royal College of Surgeons, 1830s-1850s; memorandum concerning Museum lectures, 1823-1833; lecture on the comparative anatomy and physiology of the vertebrate animals, 1844; notes, plates and drawings relating to mammalia and Owen's lecture, 1844;

notes taken by William W Cooper on lectures on comparative anatomy delivered at the Royal College of Surgeons of England, 1838-1839, revised and corrected by Owen; notes on lectures on comparative anatomy delivered at the Royal College of Surgeons of England, 1837, in Clift's hand; notes taken by T E Bryant on Owen's lectures on comparative anatomy, 1839; notes taken by Frederick Hoare Colt on lectures on physiology and morbid anatomy by Owen, 1845; Lady Owen's common-place book, [c1835-1873].

Papers of John Thomas Quekett, [1840-1854], relating to his work as Conservator of the Hunterian Museum at the Royal College of Surgeons of England, comprising diaries, 1840-1848, which include references to prominent microscopists of the time, such as Carpenter, West, Ross, Sowerby, and Smith of Smith and Beck; notebook, containing some sketches and including notes on experiments on frogs, 1841; ?draft catalogues of the Histological Series in the Museum of the Royal College of Surgeons of England, and catalogue of Pathology, [c1840-1860]; catalogue of Hewson's Preparations, [c1840-1860]; unpublished part of Quekett's catalogue of histological series; Lectures on Histology delivered at the Royal College of Surgeons 1852-1854 with annotations by Quekett; notes for lectures on histology delivered in the session 1853-1853, on the structure on the skeleton of vertebrate animals, with original drawings.