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The collection is particularly noteworthy for its full documentation of all aspects of Pirie's research, development and promotion of leaf protein for human comsumption. It is divided into the following sections:

Section A, Biographical. It includes obituaries, a copy of the Royal Society Biographical Memoir, a little documentation of undergraduate work, and historical material assembled by Pirie relating to J Brachel, J B S Haldane, F G Hopklins, and H H Mann. Miscellaneous material includes Pirie's philosophical notes on the nature of life the scientific method and other topics.

Section B, Research notebooks. These complete the sequence of numbered notebooks listed in the 'Catalogue of the Papers of Sir Frederick Charles Bawden including the papers of Alfred Alexander, Peter Kleczkowski and Norman Wingate Pirie' and also deposited in the Archives of the Royal Society. The sequence presented here runs from 1929-1996, with the missing notebooks to be found in the Bawden collection. The work documented includes Pirie's earliest research with A A Miles on 'Brucella abortus' and 'Brucella mellitensis', his research with F C Bawden on viruses, and the many facets of his work on leaf protein to the end of his life. There are also two numbered notebooks not included in the sequence which date from the 1940s.

Section C, Leaf Protein work. This is the largest section in the collection and documents the work for which Pirie became widely known. The material comers Pirie's own research work on leaf protein, his interest in leaf protein work worldwide, the promotion of leaf protein and the development of equipment, especially suitable for use in less developed countries, which could be used to extract it. There is documentation of Pirie's struggles within the Agricultural Research Council to find support for his work, his reports on progress and later fund raising for his reasearch. There is material relating to design and construction of leaf protein apparatus of various types. Pirie believed strongly that leaf protein could make a positive contribution to nutrition in poorer countries and trials were undertaken in India, Jamaica and other countries. Latterly he found backing for his work from the 'Find Your Feet' charity and this relationship is documented. Also of interest is Pirie's interest in promoting leaf protein, including sample recipes using the foodstuff.

Section D, Other Research interests. This focuses on Pirie's earlier research, including the work for which he was elected to the Royal Society and was awarded the Copley Medal. It is not extensive and should be consulted alongside the notebooks in Section B. It is presented by topic and includes research on tobacco mosaic and tomato bushy stunt viruses by Pirie and F C Bawden in the 1930's, work on 'Brucella abortus' in the 1930's and 1940's and bracken extraction in the 1950's. There is also material relating to various alternative sources of protein, including seafood, which relates to this interest in nutrition. Miscellaneous material includes documentation of Pirie's lobbying on behalf of 'biochemical engineering' research in the 1950's.

Section E, Drafts and Publications. This presents drafts and related material including publication on food resources and his 1987 book 'Leaf Protein and its by-products in human and animal nutrition', a small number of book reviews and a little editorial correspondence. The bulk of the section, however, comprises a sequence of Pirie's volumes of bound offprints, from 1929 to 1991 (with material for 1992-1996 unbound). This sequence is more than just a full record of Pirie's published work output, as intercalated or pasted to pages of the volumes are typescripts of unpublished work or work not published in full, reports on research, visits abroad etc, correspondence, and letters to the press on a wide variety of topics including nuclear weapons, the Communist Party, space exploration, scientific writing and world nutrition. The offprints themselves may bear later manuscript annotations and typescript notes by Pirtie, giving improved methods, corrections and later bibliographical references.

Section F, Visits and Conferences. These document a few of Pirie's visits 1946-1989. There is material relating to extended visits to the USA in 1946, to Czechoslovakia, the USSR and China in 1952, and later visits in connection with leaf protein work. The lack of coverage is partially compensated for by the quality of some of the documentation of the visits, including Pirie's manuscript and typescript notes and his official reports.

Section G, Correspondence. This is again partial in its coverage. The bulk relates to Pirie's work on leaf protein. There are also individual letters from significant correspondents, from the 1930's on, including A Szent-George, J B S Haldane, G C de Hervey, Sir Peter Medawar, T Svendberg, R L M Synge etc, which Piries appears to have kept for historical reasons. The correspondence is presented in alphabetical order by correspondent.

Clerk's copy of 'Opinions presentees par M. Pasteur, dans la reunion do 16 Mars 1868 au Palais de Tuileries' (Views presented by Louis Pasteur at a reunion at the Palais de Tuileries, 16 March 1668).

Letters from Sir Robert Moray to his friend Alexander Bruce, Earl of Kincardine, also known as 'The Kincardine Papers'. Bruce was sick of the ague in Bremen for part of this time, and the letters were written to alleviate the tedium of of Bruce's illness, hence ranging over topics which might not otherwise have been the subjects of correspondence. They include accounts of chemical experiments in his laboratory, his interest in magnetism, medicine in all its aspects, horticulture, fuel, whale fishing, its risks and profits, coal mining, water wheels and tide mills, stone quarrying and the various qualities of different stones, the pumping works needed for undersea coal mines at Bruce's home at Culross in Fifeshire, even to the trees whose wood was best for pipelines, and the diameter of the bore best suited to the purpose. Familiarity is shown with mathematical and surveying instruments, with music, and all sorts of mechanical devices and especially clocks and watches, more particularly the taking out of a patent in respect of a clock for use at sea for finding longitude. Bruce is advised on the choice of books over a wide range of subjects. Moray includes anecdotes to amuse his ailing correspondent; he describes his quiet life and is enthusiastic about many of his chemical experiments. Notable at the end of the letters Moray added what he described as his Masonic signature - a pentagram which also occurs in his crest.

Letters, papers and original drawings including the manuscripts of Marcello Malpighi's works published by the Royal Society.

Original Drawings of the Mammalian Eye by George Lindsay Johnson created for paper in 'Philosophical Transactions' B Volume 194, 1 and Volume 254, 207.

Some correspondence, papers, notebooks and publications of Sir James Hopwood Jeans. Early manuscripts in the series relate to Jean's education at Trinity College, Cambridge, in the form of early lecture notebooks, largely on mathematical topics. A collection of letters, 1901-1907, documents his treatment for tuberculosis at Ringwood Sanatorium, where he completed work on the theory of gases; correspondents included G H Hardy and Adam Sedgewick among others. Jean's engagements in popularizing science are represented by proofs and typescript of lectures and essays, especially those written for the BBC, 1934-1935, together with associated letters and press cuttings. The series contains collections of offprints, reprints, and extracts of published works by Jeans and others, notably from the Philosophical Transactions and the Philosophical Magazine.

Correspondence, mainly to Martin Folkes on a large variety of subjects, including administrative matters for the Royal Society.

Extensive papers of Howard Walter Florey, Baron Florey, relating to almost every aspect of his career in science and public life. The scientific materials include a complete run of laboratory notebooks, 1924-1968, files on the work for which Florey is best known, penicillin and antibiotics, 1940-1962, together with papers, research notes and photographs on mucus secretion, traumatic shock and electron microscopy. Florey's writings are preserved in the form of drafts and proofs of published items, together with relevant correspondence. His correspondence indicates the depth of his involvement in the affairs of particular organisations, notably the Oxford University School of Pathology and the Royal Society. The work of Ethel Florey (née Hayter) and Margaret Augusta Florey (née Fremantle) is also present.

A medical tract on a new system of medicinal bathing in the form of a letter addressed to the Royal Society by Bartholomew di Dominicetti, 3 Dec 1764.

Scientific and other papers sent to the Royal Society, presented at meetings of Fellows, or commissioned by the Society. They form a complementary series to the Early Letters, both of which were superseded by the Letters and Papers. Many of these items, referred to as the 'Guard Books', are duplicated in the Register Book of the Society. The classification is a simplified form of the 'Philosophical Transactions' abridgment by John Lowthorp. This arrangement was completed in 1741 by Thomas Birch. The majority of the papers in these volumes are manuscript, but a few printed documents occur throughout the series. Some of the papers are earlier in date than the grant on 15 July 1662 of the First Charter to the Society. The Committee of Trades seems to have been associated with the earlier meetings of those philosophers who subsequently became Fellows, and produced a number of practical papers, some of which were written in 1639 and which are mostly found in Volume 3(i). There are still earlier documents, mostly in Volume 25, which may have been included in the gift, in 1667, of the Arundel Library.

The correspondence, papers and scientific notebooks of Sir George Lindor Brown. The majority of notebooks relate to the investigations of Brown and his co-workers (notably Feldberg, Harvey and Maycock) at the National Institute for Medical Research, Hampstead, into neuromuscular transmission. The correspondence and remaining papers cover Brown's administrative work in the decades from the 1950's. His relationships with the Royal Society and the Medical Research Council are well represented. The papers include personal files, correspondence with institutions and individuals, working scientific notes and sets of slides.

The correspondence, papers and diaries of Sir Charles Blagden. Blagden's papers are interesting on several levels, generally for his close contact with European men of learning, and his relationship with Sir Joseph Banks. Blagden's professional researches are represented by medical notes in the boxed sequence. These are grouped with papers on other subject interests, including linguistics, e.g. a draft Tahitian-English dictionary, compiled from conversations with Omai, whom Blagden inoculated after Omai's voyage to England with James Cook. Blagden's interest in antiquities and travel is documented by diary entries, as is his intercourse with fellow scientists, particularly those associated with the founding of the Royal Institution.