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The collection comprises medical notes and associated personal material. MSS.835-853 comprise notes by Acland on scientific and medical subjects, spanning the period from his schooldays to the First World War. MSS.3652-3653 are Acland's notes of clinical lectures given in 1876-1877 at St. Thomas's Hospital by Charles Murchison (1830-1879). MSS.5798-5800 comprise loose papers: letters, wall-charts and diplomas.

One notebook on practical chemical analysis while at St Hilda's School Cheltenham, notebooks of lectures and courses while a student at London School of Medicine for Women, notes of cases seen while medical student, some later notebooks on matters of medical and surgical interest, and accounting lectures, diploma from the Comité Britannique de la Croix Rouge Française for service to France during the First World War, resolution from the Medical Women's Federation congratulating her on being made a Dame of the British Empire.

The collection comprises lectures on scientific subjects delivered by Lillie at the Mechanics' Institutes of Launceston and Hobart, Tasmania.

Records of the Physiological Society, including all the minute books from the foundation of the Society in 1876, the proposal books for candidates from 1888, correspondence, histories and photographs. The bulk of the material dates from after 1939.