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Notes of lectures on surgery by Andouille, noted in the form of questions and answers. Produced in Paris, 1735-1750.

These papers comprise the manuscript collection of F[rederick] Bacon Frank (1827-1911). They include a medieval medical miscellany (MS.550), material by or relating to the 17th century Yorkshire physician Nathaniel Johnston (MSS.3083-3086 and 6080), and some Bacon family administrative documents (MS.6079). One item relating to Nathaniel Johnston that did not form part of the Bacon Frank collection has been catalogued with it for convenience (MS.3086).

Manuscripts from the collection of the British Medical Association, formerly held in the BMA Library, Tavistock Square, London. The manuscripts were numbered and catalogued at the BMA, with two exceptions among these papers - however the numbering of surviving documents is not consecutive, so that the original collection must have contained at least 26 catalogued items and an unknown number of unrecorded acquisitions. Former BMA MSS.1-6 (transferred at the same time as the manuscripts described here) are now GC/140; one fugitive BMA manuscript was purchased separately and is now MS. 6881. The location of the remainder is not known. The contents mainly comprise transcripts of medical lectures and case notes.

Miscellaneous historical essays, written by individuals employed by or associated with the Wellcome Historical Medical Museum. Authors include Alban Doran (1849-1927), Charles Thompson (1862-1943) and Marion Spielmann (1858-1948).

Material relating to the use of nitrus oxide, chloroform and ether, mostly notes, including some on an operation carried out on Napolean III, and notes for lectures given by Clover. There is some personal material relating to Clover's education, including some family correspondence.

'On croup', an essay on croup and diphtheria by Edwards Crisp, for which he was awarded the Fothergillian medal by the Medical Society of London in 1872.

Two abridgements of Pierre Dionis's 'Cours d'opérations de chirurgie', in Italian.

Correspondence and papers of the statesman Henry Dundas both general and in his capacity as Commissioner (later President) of the Board of Control, 1783-1811.

Journal kept by John Gallop during the building of the MRC Cyclotron Unit, Hammersmith, 1949-1956, plus reports, correspondence and photographs, regarding the MRC cyclotron and many in American institutions. The 'MRC Policy' files contain reports and correspondence generated during the planning and execution of the cyclotron project, and give a good picture of the background negotiations as well as the day-to-day administration. Gallop's tutorial to the Stafford Hospital Postgraduate Medical School (G.1) summarises his view of the process. Both Gallop and J W Boag sent detailed reports of the cyclotrons which they visited in the USA in 1949-1950 (C.1-6), which Gallop prepared for publication (C.7) and lectures (C.8). The correspondence in Sections D and E contains further reports, and the personal correspondence (Section F), especially the letters from Boag, includes further thoughts on cyclotron development and use.

General Optical Council administrative records, 1959-2000: minutes of the meetings of the Council and its various committees including related memos and correspondence, Annual Reports of the Council and Committees, Notices of Motion, Registers of Opticians and Lists of Corporate Bodies.

This small but important collection is concerned with the research and development of penicillin. Heatley's laboratory notebooks (A.1-3), October 1939-June 1941, and sketches and diagrams of apparatus, 1941 (C. 1-5) form the core of the collection. The famous experiment of 25 May 1941 on the 'Curative Effect of Penicillin' on mice is recorded in notebook A.2. There are also diary entries, narratives and explanatory notes, some prepared by Heatley expressly for the collection. The correspondence and reports exchanged between Heatley and Florey (section D.) is a set of photocopies, included to provide a complete account of the collaboration between the two on the penicillin project.

The collection comprises correspondence, diaries, notes and drafts from the personal papers of members of the Hodgkin and Howard families. The bulk of the material dates from the nineteenth century.

The single largest accumulation of material relates to Thomas Hodgkin MD (1798-1866), the pathologist and philanthropist: almost half of the collection. Around the papers of this one individual, however, are numerous smaller tranches of material generated by related persons, resulting in the dividing of the archive into numerous sections dealing with other individuals or groups of people. A brief outline of the history of the family will help to explain the structure of the collection, and to set out the links between the Hodgkins and the various other Quaker families that occur in it.

The Hodgkin family were for many generations resident in Warwickshire; since the middle of the seventeenth century they had been Quakers. A handful of documents from the early eighteenth century represent this phase (section A), leading down the generations as far as John Hodgkin of Shipston (1741-1815), the grandfather of the pathologist. The first individual concerning whom there is substantial documentation is John Hodgkin of Pentonville (1766-1845), the father of the pathologist and thus referred to in the catalogue as John Hodgkin senior, who left Warwickshire for London and set up as a tutor (section B). He married Elizabeth Rickman (1768-1833), and some papers of this Sussex Quaker family are also in the collection as section C; they include material on her sister Lucy Rickman (1772-1804) who married the architect Thomas Rickman (1776-1841) and her apothecary-preacher uncle Joseph Rickman (1745-1810). Her sister Mary (1770-1851) married John Godlee (1762-1841) and had several children who occur as correspondents in this collection.

John Hodgkin senior and Elizabeth Rickman Hodgkin had four sons, of whom the first two (John and Rickman) died in infancy; the third and fourth survived. The elder of these, Thomas Hodgkin MD (1798-1866) or "Uncle Doctor" as he was known to succeeding generations, has already been mentioned. His papers, covering the wide range of his medical, general scientific and philanthropic activities, are held as section D of the archive.

Thomas Hodgkin MD married relatively late and left no children: it is from his younger brother, John Hodgkin junior (1800-1875), that the contemporary Hodgkin family descends. The latter practised law into his early forties but then, like his brother, devoted himself to philanthropic activity. His papers constitute section E of the collection. He married three times and left children by each marriage. His first wife, Elizabeth Howard Hodgkin (1803-1836), died in childbirth in 1835, her fifth child surviving only a few days. Her four other children all lived to marry and have descendants of their own. John Eliot Hodgkin (1829-1912) became an engineer and a collector of books and manuscripts; a small collection of his papers constitutes section F. Thomas Hodgkin junior (1831-1913) founded a bank (later merged with Lloyds) and had a parallel career as a historian; it was he who cared for the family archive now listed here. Documentation relating to him constitutes section G. Mariabella Hodgkin (1833-1930) married the lawyer, Edward Fry (her children included Roger Fry the art critic) and Elizabeth Hodgkin (1834-1918) married the architect Alfred Waterhouse. John Hodgkin junior's second marriage, to Ann Backhouse (1815-1845), joined the Hodgkins with a prominent Quaker family in the North-East (the Backhouses of Darlington were bankers and were based in Darlington), but the marriage lasted only a few years before her death of Bright's disease. The one child of this marriage, Jonathan Backhouse Hodgkin (1843-1926), appears in this collection chiefly as a small boy; later, he was to marry into the Pease family, a North-Eastern Quaker family of industrialists and bankers several of which occur in the archive as correspondents. Likewise, the six children of John Hodgkin's third marriage, to the Irish Quaker Elizabeth Haughton Hodgkin (1818-1904), are on the whole thinly represented here. What papers there are in this collection relating to children other than Hodgkin's two elder sons are all grouped together as section H.

Two more sections complete the Hodgkin material: I brings together miscellaneous pre-twentieth-century material that was found amongst the Hodgkin papers but not attributable to any specific individual, whilst J deals with twentieth-century members of the family, chiefly descendants of Thomas Hodgkin junior since it was his children, grandchildren and great-grandchildren who administered the collection until its presentation to the Wellcome Library.

John Hodgkin junior's first marriage, to Elizabeth Howard, linked the Hodgkins to another important Quaker family. Elizabeth was the daughter of the meteorologist and chemist Luke Howard (1772-1864), best known for his system of describing clouds which, with a few modifications, is that which is used today, and Mariabella Eliot (1769-1852), whose forename and surname recur in the Hodgkin and Howard families. The bulk of the Howard family papers are deposited elsewhere, but the family is well represented in this collection: there are papers relating to Luke Howard (section K) and to his daughters Elizabeth (section L) and Rachel (1804-1837) (section M).

Elizabeth Howard's brother Robert (1801-1871) married Rachel Lloyd (1803-1892), member of a Birmingham Quaker banking family, who was known in the family as Rachel Robert Howard to avoid confusion. Rachel "Robert" Howard was to play a notable role in the upbringing of the children of John Hodgkin junior's first marriage after the death of their mother. Her sister, Sarah Lloyd (1804-1890), married Alfred Fox (1794-1874) of Falmouth - a link to yet another significant Quaker family. Their daughter Lucy Anna Fox (1841-1934) was to marry Thomas Hodgkin junior. Correspondence of the sisters Rachel and Sarah Lloyd, and other family members, constitutes section N.

Finally, a few papers relating to the later history of the Howard family are held as section O.

Correspondence of James Jurin, including correspondence as Secretary of the Royal Society (1721-27) including with Mordecai Cary (d. 1751); John Huxham (1692-1768); Antoni van Leeuwenhoek (1632-1723); John Woodward (1665-1725) and William Nicholson (1655?-1727).

Legal papers relating to this partnership and dispute between partners over credit for inventing plastic optical lens, 1935-1938, 1944.

Letters received by Henry Lee, naturalist, 1866-1887.

Personal account books and ledger of Joseph Jackson Lister, 1836-1869, including a record of expenses of J J Lister on behalf of his son Joseph Lister, afterwards 1st Baron Lister.

Daybooks of Friedrich Wilhelm Lorinser containing surgical notes, and a collection of manuscripts, 1852-1893.

Commonplace books of extracts and notes from works published mainly during the last quarter of the 17th century and early 18th century, relating to science, medicine and mathematics. Written mainly in Latin or Italian, but with some entries in French. Author's holograph MSS. Illustrated by numerous folding and other pen-drawn diagrams and figures, and a few wash-drawings. The numeration of the volumes has been added.

Vol. I In universam scientiam mechanicam institutiones (80 ll. 3 folding pen-and-wash drawings). II Optica. Catoptrica. Dioptrica (56 ll. 4 folding pen-drawings). III Extracts and notes mainly in Latin, but a few in French on medical, scientific, mathematical and philosophical works, mostly published between c 1685 and 1700: with notices of others on Church history and doctrine, Jansenists, etc. There is a long entry towards the end of the volume on the 'Medicina mentis' by Ehrenfried Walter von Tschirnhausen [1651-1708], (352 ll. 1 folding wash-drawing, 8 folding pen-drawings, wash-and pen-drawing in the text). IV A similar collection, but with a preponderance of entries in French, included in which is a long article under the title: 'La vie de demoiselle Antoinette Bourignon [1616-1680], écrite par elle-même [etc.]' Amsterdam. 1683. The date 1705 is found on the verso of the last leaf (312 ll., 5 folding pen-drawings, and a few marginal pen-drawn figures, etc.) V Notes and extracts on geometry, mechanics, optics, physics, etc. on Cartesian principles: in Italian and Latin. At the end is a long entry entitled: 'Fisica generale sopra il lume, ed i colori per il P. Mallebranche (i.e. Nicolas de Malebranche [1638-1715]) dall'Istoria dell'Accademia delle Scienze, 1699' (224 ll. 6 folding pen-drawings). VI Netwon (Sir I.). Optica: in Latin (160 ll. 11 folding pen-drawings and marginal pen-drawn figures, etc.). VII Extracts from Newton's works on astronomy: conics, mechanics, physics, etc.: in Latin (246 ll., 10 folding pen-drawn figures, etc.). VIII Extracts on astronomy, geography, geometry, and chronology: in Latin. Written in 1713 'in hoc anno'. An added note on the first page contains the date 1714 (208 ll. 8 folding pen-drawn figures, and marginal figures, 1 folding Table). IX Sanctorius (S.). Ex commentariis in Avicennam et in Aphoirismos Hippocratis (256 ll.). A note on 'Colica' in Aphorism XXV is dated 1716. X Extracts and notes from 17th cent. medical works, notes of cases, medical receipts, etc.: in Latin (196 ll.). Illustrated with a full-page pen-drawing of a male head. Against this Marmi has written: 'Exhibeo schema communicatum mihi ab excellentissimo D[octore] Schustonio [?] Practico Esslingense ... Elegantissime Burrhus eques Mediolani (i.e. Giuseppe Francesco Borri [1627-1695]) apud Tackium (Johann Tackius [1617-1675]) Phasis p. 160 uti Macrocosmi Compendium homo existimatur, ita homo sive humanus mundus in se quoque habet proprium compendium in vultu et imago nostri corporis est facies'. The illustration shows the facial nerves supposed to correspond with those of other parts of the body. XI A similar volume, mainly in Latin, but with some entries in Italian (318 ll.). There are long extracts and notes on the works of Galen and Hippocrates. A marginal note on the 6th leaf is dated Naples 1714: another entry on 'Aqua Tofana' is dated 1715 apparently at Naples.

Pasted down as end-papers at the beginning of Vol. IV is a small folio sheet containing an engraving of 'Triangulus australis' above a decorated wreath, which includes a small meallion-portrait of Werner XVII Comes de Hapsburgo. It is numbered 132, and is apparently extracted from an unidentified volume of engravings. The identification of the author of these MSS. is based on two entries. The first is in Vol. III is a marginal note on the verso of the 12th leaf of the entry of the 'Medicina mentis' of Tschirnhausen noted above. It begins: 'Mihi Jos. Herm. M[armi]. The expansion of 'Herm' into an Italian Christian name seems doubtful, but it could be 'Hermannus' or 'Herminius' or even 'Hermes' or 'Hermete'. The second entry is however decisive. It is found also in a marginal note on the eating of cucumbers in the summer, in connexion with the onset of bile after drinking in hot weather as observed by Galen. This is definitely signed 'I. H. Marmi'. Produced in Naples?

Louisa Martindale collection, 1872-1964. The collection consists of Section A: a little personal correspondence, papers, articles, speeches and lectures by Louisa Martindale, and some personal material including notes on the glaucoma which eventually blinded her, 1872-1960; and Section B: papers concerning the Medical Women's International Association (founded 1919) of which Miss Martindale was President from 1937 to 1947. As well as her own correspondence in this capacity, 1937-1946, there is one file of the correspondence of Mme Montreuil-Strauss, Secretary of the Medical Women's International Association at his period. (Louisa Martindale destroyed the vast bulk of her case records at the time of her retirement from practice around 1950, those remaining were destroyed by her executors after her death).

Typescript signed with holograph additions and corrections entitled "Our Fathers that begat us, and other papers on the history of Medicine", by Donald Percy McDonald with a Foreword by Professor Sir Francis Fraser [1885-1964]. Inserted loose are 8 photographs intended for illustrations for the printed book. Included is a typescript letter signed by the author dated 11 July 1946 referring to an illustration of a surgeon's instrument-case belonging to Lord Lee of Fareham [1868-1947], with an initialed note of permission to use it by the owner in red crayon. Produced in Littlehampton.

Four lecture notebooks of Hedwig (Hedy) Lehmann when she was a medical student, covering the period 1942-1945. These items shed light on the curriculum and teaching methods in nursing training in England during the Second World War period. With additional original and copy documents relating to H Lehmann and her nursing career, and transcript of an interview H Lehmann gave to historians Sybille Baumbach and Beate Meyer in London May 1991 investigating the history of the Jewish community in Hamburg during the years up to and including the Second World War.

Papers of Sir William Drummond Macdonald Paton, 1930-1993, chiefly comprising papers relating to his main research interests, namely underwater physiology, histamine, synaptic transmission, drug dependence, anaesthetic mechanisms, allergy electron microscopy and the history of science, particularly medical science. The collection also includes correspondence, research papers and laboratory notebooks, and papers relating to the committee work that occupied his energies. Papers from Paton's time as both a Rhodes Trustee and a Wellcome Trustee provide further evidence of the extent of his commitments in committee.

Papers relating to Paton's Chairmanship of the Research Defence Committee (1972-77) are particularly extensive and reveal the social and political pressures of the period, the passionate challenges of the anti-vivisection lobby, as well as Paton's personal commitment to a socially responsible use of animals in scientific experimentation. Papers relating to Man and Mouse: Animals in Medical Research (1984), in which Paton set out his fundamental position on animal experimentation, provide further material on this topic.

Another field of interest in which Paton expended considerable energy was that of drug dependence, particularly the pharmacological action of cannabis. Through work in laboratory and committees, and through the media and many speaking engagements, he campaigned strenuously to warn of what he judged to be the deleterious effects of cannabis, and forged campaign alliances with American colleagues who shared his concerns.

Throughout his career, Paton maintained strong links with the Royal Navy, acting as scientific adviser and consultant on deep diving and underwater physiology. This strand of his work was of enduring interest: Paton's work on the physiological properties of gases at high pressure led directly to the development of the deep-diving breathing mixture known as 'Tri-Mix', in which nitrogen is added to helium and oxygen. Paton took great pleasure in the Royal Navy achieving, in 1980, the world's deepest dive (see D/2/14).

Notes, taken while a Student at Edinburgh University, of lectures by John Rutherford, William Cullen, John Gregory and Alexander Monro [1733-1817]. Vol. I Gregory (John). Clinical lectures. 1773 (pp 1-204). Cullen (William). Clinical lectures (pp 205-935). Vol. II Monro (A.). Lectures anatomical and physiological (pp 1-253). Operations in surgery (pp 254-365). On the first preliminary leaf, containing notes of a case, is the date 1775. Vol. III Cullen (W.). Part of a course on the Institutes of Medicine (275 pp). Vol. IV Rutherford (J.). Clinical lectures (pp 1-316). Monro (A.). Treatise on wounds in general (pp. 317-386). A treatise on bandages (pp. 368-430). This last volume is in a smaller quarto. It is dated 1752 on p 1, but this may be the date when the lectures were first given. The script is apparently the same as that of the preceding volumes.

Papers of Georges Marc Marie Sagnac including holograph papers relating to Roentgen Rays, experiments on sulphur, on optics, light- and sound-waves, and on the ether, 1897-1921.

The bulk of the collection consists of correspondence: the Singers were clearly vigorous letter writers and both Charles and Dorothea had an enormous number of family, friends and acquaintances. Unfortunately many of their letters were hand written and very few carbon copies survive. Very occasionally an attempt at methodical selection and arrangement is evident: on the whole correspondence had been kept in alphabetical order, and this has been retained in the arrangement of the collection. Dorothea and Charles' correspondence was fairly mixed (reflecting their working life together) with the exception of two distinct groups: correspondence about Dorothea's research on alchemical manuscripts, and later correspondence about her hearing aids.

The main part of the collection centres on the correspondence; this has been grouped together in a self-evident sequence: writings and biographical personal papers follow. Certain of Dorothea's papers remained clearly distinct and these have been kept together. Section E contains a variety of material relating to Jewish refugees, which had been placed on one side by Dorothea after the war for permanent preservation. It has not been listed in detail but sorted into three broad categories. The last section, comprising additional correspondence of the Singers with Sir Zachary Cope, Sir Arthur Salusbury MacNalty and Dr F N L Poynter, is not strictly part of the collection, but these groups of correspondence were given to the Institute to be placed alongside the Singer papers.

Microfilm of the letters and papers by or relating to Thomas Hodgkin MD (1798-1865) and his extended family, including his brother John Hodgkin junior (1800-1875) and the latter's father-in-law Luke Howard (1772-1864).

Although the collection is by no means comprehensive, there are interesting records of many aspects of Wilson's career.

Section A. Biographical: Brings together material relating to obituaries, tributes, honours and awards. Includes Wilson's account of his First World War experiences and his assessment of his scientific publications. Section B. Research: Although not extensive, provides documentation of a number of Wilson's principal interests including the Salmonella group of bacteria and milk hygiene. There are three laboratory notebooks with experimental data covering the period 1919-45. Section C. Public Health Laboratory Service (PHLS): Relates chiefly to the unpublished history written by Wilson after his retirement as Director of the PHLS. There is also a little material relating to laboratory design and equipment and PHLS personnel. Section D. Lectures and publications: The most substantial in the collection. There are records of Wilson's lectures for a period of forty years from 1944, extensive documentation of the later editions of Principles of bacteriology and immunity, and editorial correspondence and papers for the British Journal of Experimental Pathology and the Journal of Hygiene. Section E. Societies and organisations: Documentation of Wilson's association with ten British organisations including the Medical Research Club, Medical Research Council and Veterinary Club. The Medical Research Council material relates to the Working Party on Tristan da Cunha which was set up to supervise medical investigations when the inhabitants were evacuated to Britain after the island's volcano erupted in 1961. There is also material relating to the Research Foundation, Chicago, which specialised in tuberculosis research, on whose medical advisory committee Wilson served. Section F. Visits and conferences: Records of a number of overseas trips in an advisory capacity for the World Health Organisation, including to Ethiopia 1964, Iraq 1965, Iran, Sudan and Egypt 1971 and the Philippines 1972, and records of international microbiology congresses. Section G. Correspondence: Although not extensive, includes a chronological sequence of scientific correspondence, 1930-1987, Wilson's collection of autograph letters addressed to Topley and himself, and references and recommendations. Section H. Photographs: Photographic records of Wilson, colleagues, conferences and PHLS laboratories. Section J. 'Biographical History of Bacteriology': Manuscript of Wilson's history, with correspondence about publication.