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The collection centres on Wallich's work on biology, particularly marine biology, and his belief that other figures in the field were ignoring or plagiarising his discoveries. As well as his notes, it includes a collection of offprints by Wallich (MS.4969) and a collection of offprints by other scientists, with Wallich's comments (MS.4970).

Papers of the Burroughs Wellcome and Company (BW and Co) and from 1924 the Wellcome Foundation Ltd (WF), [1860-1995], including records of the pre-partnership S M Burroughs Company; papers relating to the founders Henry S Wellcome and Silas M Burroughs; papers of senior managers from BW and Co and WF; legal papers, particularly concerned with Trade Marks and Stamp Duty; marketing records including operational papers, a large collection of images and of publications; financial records, mainly regarding salaries; papers relating to WF sites, including the Wellcome Chemical Works, Dartford; records of Coopers, the subsidiary veterinary company, together with records of Coopers own world-wide subsidiary companies; records of related bodies, the British Insulin Manufacturers Association and The Therapeutic Research Corporation.