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The items in the collection span the work of the Junta during the 1797-1798 smallpox epidemic, comprising a circular announcing the setting up in late 1797 of local charitable societies to be co-ordinated by the Junta, and the Junta's concluding report of early 1798.

The collection comprises two sets of directives issued by the Mexico City Junta de Sanidad during the 1813 fever epidemics.