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Records of the Royal National Orthopaedic Hospital include records relating to administration (1902 - 1986); patients (1924 - 1990); staff (1962 - 1979); finance (1900 - 1979); education (1885 - 1967); legal records (1907? - 1979); associated organisations (1927 - 1984); and printed material and historic notes (1906 - 1982).

The collection also contains records of predecessor organisations: Royal Orthopaedic Hospital (1838 - 1905); National Orthopaedic Hospital (1865 - 1905); and City Orthopaedic Hospital (1857 - 1907).

Records relating to Sir John Herbert Parsons, ophthalmic surgeon, comprising scrapbook relating to his career.

Records of the National Heart Hospital, consisting of a sample of the case files kept by the physicians of the hospital between 1907 and 1963 and photographs taken by Dr John Mathias Senior Registrar of the first heart transplant in the United Kingdom in 1968.