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Papers of Sir William Drummond Macdonald Paton, 1930-1993, chiefly comprising papers relating to his main research interests, namely underwater physiology, histamine, synaptic transmission, drug dependence, anaesthetic mechanisms, allergy electron microscopy and the history of science, particularly medical science. The collection also includes correspondence, research papers and laboratory notebooks, and papers relating to the committee work that occupied his energies. Papers from Paton's time as both a Rhodes Trustee and a Wellcome Trustee provide further evidence of the extent of his commitments in committee.

Papers relating to Paton's Chairmanship of the Research Defence Committee (1972-77) are particularly extensive and reveal the social and political pressures of the period, the passionate challenges of the anti-vivisection lobby, as well as Paton's personal commitment to a socially responsible use of animals in scientific experimentation. Papers relating to Man and Mouse: Animals in Medical Research (1984), in which Paton set out his fundamental position on animal experimentation, provide further material on this topic.

Another field of interest in which Paton expended considerable energy was that of drug dependence, particularly the pharmacological action of cannabis. Through work in laboratory and committees, and through the media and many speaking engagements, he campaigned strenuously to warn of what he judged to be the deleterious effects of cannabis, and forged campaign alliances with American colleagues who shared his concerns.

Throughout his career, Paton maintained strong links with the Royal Navy, acting as scientific adviser and consultant on deep diving and underwater physiology. This strand of his work was of enduring interest: Paton's work on the physiological properties of gases at high pressure led directly to the development of the deep-diving breathing mixture known as 'Tri-Mix', in which nitrogen is added to helium and oxygen. Paton took great pleasure in the Royal Navy achieving, in 1980, the world's deepest dive (see D/2/14).

Papers, 1780s-1790s, largely of Captain Francis Light, including several hundred Malay letters, primarily letters received by Light and his business partner, Captain James Scott, from rulers and dignitaries of the Malay Sultanates.

The letters cover the history of relations, negotiations and conflicts between Light, the rulers of Kedah and the Governor General in Bengal leading up to and including the settlement of Penang in 1786 and the armed conflict of 1791. There are also letters dealing with business affairs between Light and Malay nobles such as the purchase, shipment and sale of commodities, ammunition, slaves and opium, and the maintenance of good political and economic neighbourly relations; letters from the Sultanate of Selangor; letters from royal merchants at the Malay courts; and letters concerning trade from various rulers and nobles in the Peninsula and Sumatra, especially from Aceh, Asahan and other North-Sumatran states.

In addition, the collection contains several dozen letters and documents from the same period relating to Bencoolen (Benkulen) and the West Sumatran Presidency, which are unrelated to Light.

Records and collection of manuscripts of the Hunterian Society, 1676-1989. The manuscript collection includes extensive letters and papers relating to the Hunter and Baillie families.

Papers, 1822-1917, of and relating to the Rev David Hill, including journals, 1865-1889 (some gaps); Hill's notes, sermons and addresses, 1863-1875 and undated, including some lantern slides, the subjects including the Old Testament, missionary work, China, including the opium trade and Chinese literature, and Hill's visit to America; letters from Hill to various members of his family, 1847-1896, and other correspondents, 1873-1895; various letters, 1847-1917, some to Hill, but including miscellaneous others; photographs of Hill and other subjects, including Chinese costumes; books belonging to Hill, 1857-1895, such as Bibles, a prayerbook, and hymnbooks; woodcut for visiting card; correspondence and papers, 1858-1897 and undated, some printed, relating to missionary work and other affairs in China, including anti-foreign riots, 1891; papers, 1877-1881 and undated, relating to the opium trade; Central China Lay Mission cash book, 1894-1899; printed papers, 1822-1917, including material relating to missionary work in China and to Methodism, including Methodism in York.

Papers of Reginald Hale-White chiefly relating to the Fellowship for Freedom in Medicine, including correspondence; address at the Tunbridge Wells meeting of the Fellowship for Freedom in Medicine, Apr 1953; typescript drafts of reports; press-releases and printed Bulletins of the Fellowship for Freedom in Medicine, 1948-1972 (some were added to the collection by Hale-White's widow after his death). Also comprises material about his other medical interests including correspondence and other papers about the Government proposal to ban the manufacture and import of heroin in the United Kingdom, and about Hale-White's participation in opposing the ban, 1955-1956; copies of letters from Hale-White to the Daily Telegraph and the British Medical Journal, 1958-1967 and typescripts of speeches and lectures given by Hale-White, some annotated by him in manuscript.

Copies of papers relating to his life and career and other family members, 1911, 1915, 1932, comprising: letter from Lt Col Sir George Roos-Keppel, Chief Commissioner and Agent to the Governor General, North West Frontier Province, to the Secretary to the Government of India, Foreign Department, reporting the capture of a party of raiders at Tarnab and commending various army and police officers, including Michael Donlea, Inspector of Police, North West Frontier (brother of Patrick), for their services in the incident, 2 March 1911; photograph [of raiders referred to in the above letter, 1911]; press cuttings describing charge of 21Lancers at Shabkadr, Aug 1915; brief typescript account of opium production and the organisation of Opium Department, United Provinces of Agra and Oudh, 1932; copy of letter to Mrs Lucy Sophia
Le Marchand (aunt by marriage of Patrick's wife) from Maj Cecil Allanson, 1/6 Gurkha Rifles describing the death of her son, Lt John Wharton Jones Le Marchand, Gallipoli, 1915.

Bad trip to Edgewood consists of, interview transcripts, research files and videos for a television documentary on US Army testing of chemical and biological warfare agents on human 'guinea pigs' between 1955 - 1975, and includes files of mainly photocopied documents, reports, scientific articles, letters and newspapers articles, with some printed brochures, as well as videotapes. There is also a video copy of Bad trip to Edgewood which was produced by Michael Bilton, Yorkshire Television, and broadcast as a First Tuesday film in March 1993.

The files focus on secret projects carried out by the US Army Chemical Corps at the Aberdeen Proving Ground, Edgewood, Maryland USA, between 1955-1975, in which US Army volunteers were used to test the effects of lysergic acid diethylamide (LSD), benzilates such as BZ (3-quinuclidinyl benzilate, also known a QNB) and glycolates.

The testing programs were suspended in 1975 when information about them became public. A number of volunteers claimed to have suffered long term mental health effects from the tests. They also claim they were not informed at the time of immediate or long term effects of the agents tested. In 1977 US Army notified 686 volunteers who has been tested with LSD and conducted a follow up study of their health. The LSD follow-up study report released in 1980 found 'the majority of subjects evaluated did not appear to have sustained any significant damage from their participation in the LSD experiments'.

There are notes and transcripts of interviews conducted with former US Army personnel who were volunteers in the research programmes, individuals involved in the running testing programs, medical experts and lawyers.

Several files relate to particular law suits including that of Sgt James B Stanley, US Army, volunteer at Edgewood during 1958. In 1977 he was informed by the army that he had been given LSD as part of the testing program. In 1987 a controversial judgement by the US Supreme Court found against Stanley, effectually granting immunity from liability for money damages for all federal officials who intentionally violate the constitutional rights of those serving in the military.

Other notable cases frequently mentioned in the files include that of Frank Olson and Harold Blauer. Dr Frank R Olson, US Army scientist at Fort Detrick, apparently suicided, on 28 November 1953. In 1975 the Commission on CIA Activities within the United States (the Rockefeller Commission) revealed Olson had been given LSD without his knowledge while attending a meeting of Central Intelligence Agency (CIA) personnel eight days before his death. A civilian, Harold R Blauer died on 8 Jan 1953 after being given a lethal injection of Experimental Agent 1298 supplied by the US Army Chemical Corps to the New York State Psychiatric Institute where he was a patient. A 1975 Senate investigation revealed the facts of his death. Files also contain material on bacteriological testing by the Army and the CIA carried out in Washington DC, Florida, San Francisco, and New York. Particular reference is made to the case of Edward Nevin, a civilian, who died on 1 Nov 1950 in San Francisco as a result of a rare bacterial infection Serratia Marcescens, which coincided with a significant and unexplained outbreak of this infection between Oct 1950 and Feb 1951. In 1976 it was revealed that the US Army had conducted bacteriological warfare experiments with Serratia Marcescens over San Francisco Bay during September 1950.

There is a small amount of material relating to the role of American Citizens for Honesty in Government, a Church of Scientology sponsored organisation who campaigned during 1979 for a full investigation of the testing and storage of BZ and compensation for volunteers suffering long term effects from testing of the substance, and to chemical testing carried out in the UK at Porton Down, Wiltshire, UK and production of chemical agents at Nancekuke Base, Cornwall, and Anglo American cooperation in this area.