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Born, Berkeley, Gloucestershire, 1749; educated at private schools at Wootton-under-Edge and Cirencester; apprenticed to Daniel Ludlow of Sodbury, a surgeon; pupil-resident in the house of John Hunter, 1770-1772; employed by Sir Joseph Banks to prepare specimens from Captain Cook's voyage; studied at St George's Hospital; practiced at Berkeley, 1773; continued to correspond with John Hunter on many subjects; member of medical societies at Rodborough and Alveston, reading papers on medical subjects and natural history; Fellow, Royal Society, 1788; MD, University of St Andrew's, 1792; continued his investigations into cow pox and small pox; vaccinated a boy James Phipps with cow pox and then small pox, who contracted cow pox but not small pox, 1796; published An inquiry into the causes and effects of the variolæ vaccinæ, a disease discovered in some of the Western Counties of England ... known by the name of the cow pox, 1798; sent cow pox material throughout England and abroad for vaccinations; vaccinated nearly 200 people at Petworth, Sussex, 1800; granted £10,000 by Parliament in recognition of his work, 1802; Royal Jennerian Society established to promote spread of vaccination in London, 1802; replaced by the National Vaccine Establishment, 1808; continued to work and publish on vaccination; died, 1823, Berkeley, Gloucestershire.
Publications include: Cursory observations on Emetic Tartar [1780?]; An inquiry into the causes and effects of the variolæ vaccinæ, a disease discovered in some of the Western Counties of England ... known by the name of the cow pox (Printed for the author: London, 1798); Further observations on the Variolæ Vaccinæ or Cow Pox (London, 1799); A comparative Statement of facts and observations relative to the cow-pox with Dr Woodville (London, 1800); The origin of the Vaccine Inoculation (London, 1801); On the varieties and modifications of the vaccine pustule, occasioned by an herpetic state of the skin (Cheltenham, 1806; Gloucester reprinted, 1819); Facts for the most part unobserved, or not duly noticed, respecting variolous contagion (London, 1808); Letter from E. J. to W. Dillwyn on the effects of vaccination, in preserving from the small-pox. To which are added sundry documents relating to vaccination, etc (Philadelphia, 1818); A letter to C. H. Parry, M.D., ... on the influence of Artificial Eruptions in certain diseases. ... With an inquiry respecting the probable advantages to be derived from further experiments (London, 1822); The Note-Book of Edward Jenner in the possession of the Royal College of Physicians of London (Oxford University Press, London, 1931).