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George Langstaff was born in Richmond, Yorkshire, in c 1780. He studied medicine at St. Bartholomew's Hospital, London. He travelled to the East and West Indies and became a naturalist and zoologist, collecting specimens which would become his museum. He became Surgeon to the workhouse of St Giles's Cripplegate where he had abundant opportunities of studying both pathology and practical anatomy. He became a Fellow of the Royal Medico-Chirurgical Society, in 1814. He published the catalogue of his museum, Catalogue of the Preparations illustrative of normal, abnormal, and morbid structure, human and comparative, constituting the Anatomical Museum of George Langstaff in 1842. Part of the collection was bought by the Hunterian Museum, and the remainder bought by the Royal College of Surgeons of England. He died in 1846.