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Kensington Infirmary and Kensington Workhouse were administered by the Kensington Board of Guardians until 1930. Kensington Workhouse became known as Kensington Institution in 1912 and Kensington Infirmary became St Mary Abbot's Hospital in 1923. In 1930 when the London County Council took over the two hospitals, St Mary Abbot's Hospital was designated a type A hospital for the acute sick, and Kensington Institution became a type B hospital for the chronic sick. In 1931 on the retirement of the Master of Kensington Institution, the hospital was placed under the charge of a Medical Superintendent as a first stage in integrating the two hospitals. This was carried a step further in 1933 when the Institution was renamed St Mary Abbot's Hospital (Institution).
From 1938 St Mary Abbot's Hospital became St Mary Abbot's Hospital (I) and St Mary Abbot's Hospital (Institution) became St Mary Abbot's Hospital (II), until 17 June 1944 when Hospital (II) was closed due to enemy action. The two hospitals were eventually united formally in 1948 when they were taken in to the National Health Service.
In 1838, the surgeon James Yearsley founded the Metropolitan Ear Nose and Throat Hospital, in Sackville Street, W1. It was the first hospital to specialise in diseases of the Ear, Nose and Throat. The hospital was transferred to Saint Mary Abbots Hospital in 1953, where it retained its identity as a specialist hospital until 1985 when it was removed from the control of Saint Mary Abbots and became part of the Ear, Nose and Throat Department of the new Charing Cross Hospital.