The collection covers both Pettigrew's medical and antiquarian activities, which are intermingled in the material's arrangement. The medical items include correspondence with many medical figures, medical jurisprudence (an Anniversary Oration delivered to the Medical Society of London), corpulence, hydrophobia, medical observations by army officers in India, and an autobiographical memoir of the philanthropist and prison-reformer James Neild (1744-1814), transcribed by Pettigrew and incorporated into his life of John Coakley Lettsom M.D. The antiquarian items include material on Kett's Rebellion, Hindu deities, the library of the Duke of Sussex and correspondence with the Italian antiquary Giovanni Spano (1803-1878) and Gaetano Cara, as part of Pettigrew's role as Vice-President of the British Archaeological Society. Types of material held include notebooks, loose papers, correspondence and diplomas.
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