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Born, London, 1714; educated, educated privately at 'Darne' (Darenth), Kent; apprentice to Edward Nourse, assistant-surgeon at St. Bartholomew's Hospital, 1729-1736; admitted to the Barber-Surgeons' Company, 1736; lecturer on anatomy, 1753, master, 1765, Corporation of Surgeons; assistant-surgeon, 1744, surgeon, 1749, senior surgeon, 1765-1787, St Bartholomew's Hospital; introduced many improvements to surgery; became the leading surgeon of his time, and perhaps the earliest 'modern' surgeon; thrown from his horse, and suffered a compound fracture of the leg, 1756, that type of fracture becoming known as a 'Pott's fracture'; fellow of the Royal Society, 1764; instituted a course of lectures for the pupils at St Bartholomew's Hospital, 1765; honorary fellow, Royal College of Surgeons of Edinburgh, 1786; honorary member, Royal College of Surgeons in Ireland, 1787; Governor, St Bartholomew's Hospital, 1787; died, 1788.
Publications include: A Treatise on Ruptures (C Hitch & L Hawes, London, 1756); An Account of a particular kind of Rupture, frequently attendant upon children, and sometimes met with in adults; viz. that in which the intestine, or omentum, is found in the same cavity, and in contact with the testicle (London, 1757); Observations on that Disorder of the Corner of the Eye, commonly called Fistula Lachrymalis second edition (L Hawes & Co, London, 1763); Remarks on the disease commonly called a fistula in ano (L Hawes, London, 1765); A Treatise on the Hydrocele, or Watry Rupture, and other Diseases of the Testicle second edition (L Hawes, London, 1767); Observations on the nature and consequences of those injuries to which the head is liable from external violence, etc (L Hawes, London, 1768); Some few General Remarks on Fractures and Dislocations second edition (L Hawes, London, 1773); Chirurgical Observations relative to the Cataract, the polypus of the nose, the cancer of the scrotum, ... ruptures, and the mortification of the toes, etc (London, 1775); The Chirurgical Works of Percival Pott (London, 1775); Farther Remarks on the useless state of the lower limbs in consequence of a Curvature of the Spine, being a supplement to a former treatise on that subject (London, 1782); Observations on Chimney Sweeper's Cancer [London, 1810?].