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The Alexandra Hospital for Children with Hip Disease was opened on 12 March 1867. Founded by a group of women (two of whom were nurses at the nearby Great Ormond Street Hospital), it was initially based in 19 Queen Square, Bloomsbury, London. Until 1870, it was known as the House of Relief for Children with Chronic Diseases of the Joints, and from 1870 to 1881 the Hospital for Hip Diseases in Children. Hip disease, or tuberculous arthritis, was a common disease at this time.
The demand for the hospital's beds was such that 18 Queen Square was purchased in 1872 to provide additional accommodation. 17 Queen Square was acquired in 1873 and properties in Queen Square Place were added over the following years. In 1881 the hospital was re-named after Princess Alexandra, and by 1897 the Alexandra Hospital had sixty-eight beds. However, the buildings in which the hospital was accommodated were dilapidated and unsanitary and in 1898 a decision was taken to re-build. The hospital took temporary accommodation at 34 Guilford Street, Russell Square, London whilst the rebuilding took place. The new hospital buildings opened on 20 July 1899. The Alexandra Hospital also had convalescent homes at Helen Branch Hospital, Bournemouth, Hampshire (1874-1993); Wash Well Home, Painswick, Gloucestershire (1893-1914); and Clandon Branch Hospital, East Clandon, Surrey (1903-1936).
In 1920, the Alexandra Hospital moved from its central London location. It took up residence at the Kettlewell Home in Swanley, Kent, the site of St Bartholomew's Hospital's convalescent home. The Alexandra Hospital had maintained close ties with Bart's from its foundation in 1867, and many of its medical staff had served both institutions. These links were now strengthened and on 3 November 1922, the hospitals amalgamated. After the amalgamation the Committee of Management was renamed the Committee of the Alexandra Hospital and Kettlewell Home.
In 1940, the Alexandra Hospital moved for the final time, to Stockwood Park near Luton, Bedfordshire, a property on lease from Luton Borough Council. It was later proposed that a further move be made to Nyn Park in Hertfordshire, but these suggestions came to nothing and in 1958 the Ministry of Health closed the Alexandra Hospital.