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Samuel Ashwell was Assistant to James Blundell, Lecturer in Midwifery at Guy's Hospital Medical School from 1825 to 1834 (and previously at the School of the United Hospitals). Ashwell was appointed Lecturer on Midwifery at Guy's Hospital in 1834 on Blundell's resignation, and was probably responsible for arrangements of the new Lying-in Charity to attend child birhs in the vicinity. He was also responsible for the hospital wards for diseases for women, established in 1831. He resigned the lectureship in 1849.
Publications include: A Practical Treatise on Parturition ... To which are appended, two papers ... on abdominal surgery, the other on transfusion; presented by Dr. Blundell (Thomas Tegg, London, 1828); A Practical Treatise on the Diseases peculiar to Women, etc (Samuel Highley, London, 1844).