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The Brook Hospital opened in 1896 as one of the hospitals for infectious diseases built and maintained by the Metropolitan Asylums Board. It was situated on Shooters Hill Road in Woolwich. In 1930 on the dissolution of the Metropolitan Asylum Board the hospital was transferred to the London County Council. In 1938 it had 552 beds and was one of the principal London County Council fever hospitals for such diseases as scarlet fever and measles.
During the Second World War the Brook Hospital was also used as a general hospital treating service personnel, air raid casualties, and civilians. In 1948 on the formation of the National Health Service it came under the control of the South East Metropolitan Regional Hospital Board and the Woolwich Group Hospital Management Committee, who linked it with the Memorial Hospital transferring all the medical beds from the Memorial Hospital to the Brook, which was renamed the Brook General Hospital. In 1952 it had 414 beds in use.
On the reorganisation of the NHS in 1974, responsibility for Brook Hospital passed to the South East Thames Regional Health Authority and Greenwich and Bexley Area Health Authority, succeeded in 1982 by Greenwich Health Authority. The hospital closed in 1995 on the transfer of services by Greenwich Healthcare NHS Trust to Queen Elizabeth Hospital, Woolwich.