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Henry Cline was born in London in 1750. he was educated at Merchant Taylors' School. He was apprenticed to Thomas Smith, surgeon to St Thomas's Hospital, London, and during his apprenticeship he lectured for Joseph Else, lecturer on anatomy at the hospital. Cline obtained his diploma from Surgeon's Hall in 1774, and in the same year attended a course of John Hunter's lectures. Cline became a surgeon to St Thomas's in 1784. He was elected a member of the court of assistants of the Surgeons' Company in 1796. He became an examiner at the Royal College of Surgeons in 1810, and in 1812 resigned his appointments at St Thomas's. He was succeeded as surgeon by his son Henry (d 1820). He became master of the College of Surgeons in 1815, and in 1816 delivered the Hunterian oration, which was never published. He gave the oration again in 1824. In 1823 Cline was President of the College, the title having been changed from that of Master in 1821. He died in 1827.