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Born, Brooke Hall near Norwich, 1768; educated at home; apprenticed to his uncle, William Cooper, surgeon to Guy's Hospital, 1784; soon after transferred to Henry Cline, surgeon to St Thomas's Hospital; Edinburgh Medical School, 1787-1788; Demonstrator of anatomy, St Thomas's Hospital, 1789; joint lecturer with Cline in anatomy and surgery, 1791; lectured on anatomy at the College of Surgeons, 1793-1796; Surgeon, Guy's Hospital, 1800-1825; commenced private practice; Fellow, Royal Society, 1802; made many post-mortem examinations, and often in contact with 'resurrectionists'; a founder and first treasurer, 1805, President, 1819-1820, Medical and Chirurgical Society of London; Professor of Comparative Anatomy, Royal College of Surgeons, 1813; performed a small operation on George IV, 1820; baronet, 1820; examiner at the College of Surgeons, 1822; resigned his lectureship at St Thomas's, 1825; instigator of the founding of a separate medical school at Guy's Hospital, 1825; Consulting Surgeon, Guy's Hospital; President, College of Surgeons, 1827, 1836; Sergeant-Surgeon to King William IV, 1828; Vice-President, Royal Society, 1830; died, 1841.
Publications include: The Anatomy and Surgical Treatment of Inguinal and Congenital Hernia (Crural and Umbilical Hernia) (printed for T Cox; sold by Messrs Johnson, etc, London, 1804); A Treatise on Dislocations, and on Fractures of the Joints (Longman, Hurst, Rees, Orme & Brown; E Cox & Son, London, 1822); The Lectures of Sir Astley Cooper, Bart., F.R.S. ... on the Principles and Practice of Surgery: with additional notes and cases, by Frederick Tyrrell 3 volumes (Thomas & George Underwood, London, 1824-1827); Illustrations of the Diseases of the Breast ... In two parts (Longman, Rees, Orme, Brown & Green: London, 1829; Lectures on the Principles and Practice of Surgery Second edition (F C Westley, London, 1830); Observations on the Structure and Diseases of the Testis (Longman, Rees, Orme, Brown & Green; Highley & Underwood, London, 1830); The Anatomy of the Thymus Gland (Longman, Rees, Orme, Green & Brown, London, 1832).