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Forest Gate Hospital was established in 1913 by the West Ham Board of Guardians, as the Forest Gate Sick Home. Accommodation was provided for the chronic sick, together with 50 mentally handicapped adults and 25 mentally handicapped children, including epileptics. Some maternity patients were also admitted and their numbers grew steadily. The buildings originally housed an Industrial School established by the Guardians of the Poor of the Whitechapel Union in 1854. In 1869, management of the School was transferred to the Board of Management of the Forest Gate Schools District (comprising Hackney, Poplar and Whitechapel Unions). A disastrous fire in 1890 caused the deaths of 20 of the 84 resident boys. Poplar Union took over management of the School in 1897, and it continued as an industrial training school until its closure in 1906. In 1908 it reopened as a branch workhouse for the Poplar Union, but closed again in 1911.
The buildings were purchased in 1912 by the West Ham Board of Guardians, and the Forest Gate Sick Home opened in 1913. Under the Local Government Act, 1929, the Sick Home was transferred in 1930 to the County Borough of West Ham Public Assistance Committee. By 1930, the Hospital had 550 beds for chronic sick and mentally handicapped patients, including a Maternity Unit which was opened with 64 lying-in beds. In 1931 temporary buildings were erected to provide an additional 200 beds for chronic sick patients transferred from the Central Homes, bringing the bed complement up to 723. During the Second World War, patients were evacuated to the South Ockendon Colony, Essex. Much of the accommodation for non-maternity patients at the Hospital was destroyed by bombing, including 2 direct hits which necessitated the demolition of 5 wards. In view of this and the unsuitability of some of the accommodation, the bed compliment was reduced to 201. In 1944 management of the Hospital was transferred to the Public Health Committee of West Ham County Borough. By 1945, accommodation for 128 residents patients had reopened and the building of a new Maternity Unit with 102 beds began in 1947.
The Hospital became part of the National Health Service in 1948, and management was transferred to the Regional Hospitals Board. The Maternity Unit was expanded into a number of existing wards. In 1974, the Hospital, which by now had 116 beds and was called Newham Maternity Hospital, became part of Newham Health District under the City and East London Area Health Authority (Teaching). With the opening in 1985 of Phase 2 of Newham General Hospital, which included Maternity beds and a Special Care Baby Unit, the Hospital was closed by Newham Health Authority.