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John Henry Gaddum was born on 31 March 1900 in Hale, Cheshire, the eldest of 6 children. His father was a silk importer who did much charitable work and who had a great influence on his son. He was educated at Miss Wallace's day school in Bowdon, Cheshire, then Moorland House School, Heswall, Cheshire, and from 1913 at Rugby School. He was encouraged to take up science by F A Meyer who later became headmaster of Bedales. He won two leaving exhibitions - one general, one for mathematics. In 1919 he went to Trinity College Cambridge on an entrance scholarship for mathematics, and read medicine. He won a senior scholarship at Trinity in 1922 and obtained second class honours in the Science Tripos (Part II) in Physiology. In 1922 he became a medical student at University College Hospital, London. In 1925 he applied for and won a post at the Wellcome Research Laboratories under J W Trevan, writing his first paper on the quantitative aspects of drug antagonism. In 1927 he went to work for Sir Henry Dale at the National Institute for Medical Research in Hampstead, where he stayed for six years, then accepted the Chair of Pharmacology at the University of Cairo in 1934. In 1935 he was appointed Professor of Pharmacology at University College London, and in 1938 he took the Chair of Pharmacology at the College of the Pharmaceutical Society, London. After the war broke out, he worked at the Chemical Defence Research Station, Porton Down, then later was for a short time in the Army as Temporary Lieutenant-Colonel. In 1942 he accepted the Chair of Materia Medica in the University of Edinburgh, where he was happy and built up an outstanding research department which attracted many scientists from abroad. Extra-mural activities became more time-consuming and in 1958 he was invited to become the Director of the Institute of Animal Physiology in Babraham, Cambridge, by the Agricultural Research Council. He enjoyed learning new things, so accepted the post and staffed the Institute with the finest physiologists, with the result it became one of the great international centres for research in physiology and pharmacology. A year before his death he was knighted and awarded an honorary LL.D, Edinburgh. He was a Fellow of the Royal Society. In 1929 he married Iris Mary Harmer, M.B., B.Chir., M.R.C.P., daughter of Sir Sidney Harmer, FRS, a zoologist, and Laura Russell.