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Thomas Graham was born in Dumfriesshire, Scotland, and studied medicine at Edinburgh University from 1835 (MD 1838). In 1841 he was appointed an assistant naval surgeon by the Board of Admiralty, serving initially at Melville Hospital, Chatham, then aboard HMS Warspite in home waters, in the Atlantic, American waters, and the Mediterranean between 1841 and 1846. In that year he was commissioned as assistant surgeon of HMS Madagascar, serving mainly in the west of Ireland, where he took a prominent part in assisting the relief of distress during the Famine. In 1849 he was commissioned with the same rank to HMS Hastings, based in Hong Kong, travelling out to meet her aboard the troopship Apollo. In March 1850 he was promoted surgeon, to serve on HMS Phlegethon at Whampoa (now Huangpu), but died a few weeks later on 13 July 1850 from malaria. He is buried on Dane's Island, near Canton (Guangzhou).