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The manor of Great Stanmore was owned by St Alban's Abbey at the time of the Norman Conquest. The manor was initially known as Stanmore-the first recorded division of Stanmore into "Great" and "Little" is in the Domesday Book. The Manor of Little Stanmore was also known as Canons. In 1709 Little Stanmore, and in 1715 Great Stanmore, were sold to James Brydges, who became duke of Chandos in 1719. He rebuilt the mansion house of Canons in ostentatious style, including marbles, rare woods, ceiling paintings and tapestries. The grounds included canals, hothouses, an aviary and sculptures. His son Henry was forced by debts to break up the Canons estate, much of the furniture and collections of fine art were sold and the house was pulled down in 1753. The family retained the lordship of the manors.
The third and last Duke of Chandos was James Brydges. His daughter, Lady Anna Elizabeth (1780-1836), was married to Richard Temple Nugent Grenville, (1776-1839), known as Earl Temple, the son of the Marquess of Buckingham. Richard adopted the surname Temple-Nugent-Brydges-Chandos-Grenville and was made 1st Duke of Buckingham and Chandos in 1822. Their son Richard Plantagenet Temple-Nugent-BrydgesChandos-Grenville sold the manor in 1840.
Information from: A History of the County of Middlesex: Volume 5: Hendon, Kingsbury, Great Stanmore, Little Stanmore, Edmonton Enfield, Monken Hadley, South Mimms, Tottenham (1976) (available online).