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The Guy's Hospital Group was formed in 1948 when the National Health Service was established in the wake of the National Health Service Act 1946. It comprised Guy's Hospital, including Nuffield House and York Clinic, and the Evelina Hospital for Sick Children, including the Eleanor Wemyss Home.
When the National Health Service was re-organised in 1974 into Area Health Authorities, which were then split into Districts, the Guy's Hospital Group became Guy's Health District (Teaching) of the Lambeth, Southwark and Lewisham Area Health Authority.
By now this included the Royal Dental, Saint Olave's and New Cross Hospitals, in addition to Guy's and the Evelina.
There were further administrative changes to the National Health Service in 1982 and 1990. In 1982, Guy's Health District (Teaching) was merged with Lewisham Health District to form the Lewisham and North Southwark Health Authority.
In 1990, Guy's Hospital was established as a National Health Service Trust.
Guy's Hospital merged with Saint Thomas' Hospital in 1993 to form the Guy's and Saint Thomas' Hospital Trust after the Tomlinson report in 1992 recommended that one of the two should be closed.