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Horder qualified MB 1898, MD 1899. After holding house appointments at St Bartholomew's Hospital and the Hospital for Sick Children, Great Ormond Street, he was appointed to the honorary staff of the Great Northern Hospital in 1900 and the Cancer Hospital, Fulham, in 1906. In 1912 he became a consultant at St Bartholomew's and remained there until his retirement in 1936 (Senior Physician 1933-1936). He was attached in a consulting capacity to the Royal Northern Hospital, the Royal National Orthopaedic Hospital, the Royal Cancer Hospital and several hospitals outside London. During the First World War he was Captain, RAMC, attached to 1st London General Hospital. He was knighted in 1918 and made a baronet in 1926 and a baron in 1933.
He was appointed honorary consultant to the Ministry of Pensions in 1939 and medical advisor to London Transport in 1940 and to Lord Woolton at the Ministry of Food in 1941. He was president of the Eugenics Society from 1935 until his death, chairman of the Empire Rheumatism Council 1936-1953, and chairman of the scientific advisory committee of the British Empire Cancer Campaign (BECC) and later of its grand council, as well as being involved in many other bodies as diverse as the Family Planning Association (FPA) and the Noise Abatement Society. Further details can be found in obituaries and appreciations in file GP/31/A.3, and in the Oxford Dictionary of National Biography.