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Horton Hospital was founded in 1902 by the London County Council as Horton Asylum. It was one of five mental hospitals opened on the Horton Estate, Epsom. In 1915 Horton Asylum became Horton (County of London) War Hospital, which was commanded by Lieutenant-Colonel J.R. Lord. This required the transfer of 2143 patients to sister hospitals. From 1918 until 1937 Horton Asylum became known as Horton Mental Hospital. The Second World War saw Horton once again become a war hospital as part of the Emergency Medical Service, returning to its function as a mental hospital in 1949.
Upon the establishment of the National Health Service in 1948, Horton Hospital became part of the South West Metropolitan Region. Between 1974 and 1982 the Hospital was part of the North West Thames Region within the North East District (Teaching) Health Authority. From 1982 the Hospital was part of the North West Thames Region within the Victoria District Health Authority and in 1985 it became part of the Riverside Health Authority. The hospital was closed in 1998.