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John Hunter and his brother William ran a School of Anatomy in Great Windmill Street, London which was opened by William in 1768. John practised as surgeon in Golden Square from 1763, was Surgeon to St George's Hospital from 1768, and enjoyed widespread recognition as the leading teacher of surgery of his time. Edward Jenner was born in Berkeley, Gloucestershire, 1749, and was a resident pupil of John Hunter from 1770 to 1772. He returned to practice medicine at Berkeley in 1773, but continued to correspond with John Hunter on many subjects until Hunter's death in 1793. Jenner went on to investigate and experiment with vaccinations for small pox with cow pox, publishing articles and books on the subject. Hunter maintained a long correspondence with his former pupil which ended only with Hunter's death in 1793. Only Hunter's letters survive.