Showing 8 results

Material relating to the use of nitrus oxide, chloroform and ether, mostly notes, including some on an operation carried out on Napolean III, and notes for lectures given by Clover. There is some personal material relating to Clover's education, including some family correspondence.

The papers consist primarily of Daly's meticulous records of experiments, covering the period 1919-1965, in a series of large notebooks, all indexed by him, some of which represent compilations of material gathered over many years from a variety of sources. There is also correspondence with, and biographical information regarding, several eminent physiologists including Sir Edward Sharpey-Schafer and Sir Charles Sherrington. William Sharpey is represented by five autograph letters to Sir Charles Lyell, 1858-1871.

The vast majority of the material relates to Dent's research and clinical interests and falls into four main categories: correspondence files; files created around the publication of papers; lecture notes and symposium papers; and case/research notes. There are also smaller quantities dealing with other aspects of his career, such as the administration of UCH Metabolic Ward. The papers thus reflect most of Dent's scientific and clinical interests. This research is mainly represented by the abstracted documentation which he kept with drafts of his published papers (see section E.1) and also by correspondence about cases and clinical case notes (see section C.5). To a lesser degree they also illustrate the work at the laboratory bench which underpinned much of this research. For example, a file of unidentified paper chromatograms has been preserved (C.2/10) to illustrate one of Dent's methods of working, as described by his colleague, Heathcote, and quoted in the Biographical Memoirs of Fellows of the Royal Society, 1978: 'Paper chromatograms were not to be thrown away. They were filed and, since the colours faded, the outline of each spot was drawn in and the intensity of the colour was indicated by a number.' The way in which Dent compiled a large series of files around drafts of scientific papers also illustrates the importance of the published paper to him as a stage in the research process. An incomplete collection of reprints of Dent's published papers may be found in section E.2 of the collection.

Much of the collection is made up of diaries and notebooks relating to expeditions sent to Africa by the Liverpool School of Tropical Medicine to study diseases such as malaria and trypanosomiasis. From Todd's subsequent career there is also material on journeys to Western Canada to study Swamp Fever in horses and to Poland to study Typhus, some general notes on tropical diseases, a laboratory notebook on experiments with fever ticks and a paper on the Congo Free State as a political unit. The dates covered are 1901-1920. A final block of material consists of letters and loose papers including sketches, covering 1890-1949.

This small but important collection is concerned with the research and development of penicillin. Heatley's laboratory notebooks (A.1-3), October 1939-June 1941, and sketches and diagrams of apparatus, 1941 (C. 1-5) form the core of the collection. The famous experiment of 25 May 1941 on the 'Curative Effect of Penicillin' on mice is recorded in notebook A.2. There are also diary entries, narratives and explanatory notes, some prepared by Heatley expressly for the collection. The correspondence and reports exchanged between Heatley and Florey (section D.) is a set of photocopies, included to provide a complete account of the collaboration between the two on the penicillin project.

Notes of lectures (on medical jurisprudence), on cases, and on diseases such as material on digestion and on hip disease, 1877-[1885].

The collection provides good documentation of many aspects of McIlwain's career and his contribution to the development of neurochemistry in the UK and internationally.

Section A, Biographical, brings together obituaries, curricula vitae and bibliographies, and material relating to the various stages of McIlwain's scientific career, especially in the 1930s and 1940s, his appointment to the Biochemistry Chair at the Institute of Psychiatry in 1954 and the symposium held in his honour on his retirement in 1980. The section also presents a significant body of material relating to McIlwain's undergraduate studies at King's College, University of Durham, including essays and notebooks.

Section B, Institute of Psychiatry, is principally papers relating to the activities of McIlwain's own Department of Biochemistry and especially its teaching programme in neurochemistry. There is also material relating to various government and University of London enquiries into medical education.

Section C, Research, includes copies of McIlwain's M.Sc. and Ph.D. theses, notes, drafts and reports for early work in the 1930s and correspondence 'from the Lab' for the 1930s and 1940s.

Section D, Publications, lectures and broadcast, is the largest in the collection. It presents significant documentation, especially correspondence, relating to his textbook Biochemistry and the central nervous system which went through five editions, 1955-1985, and important editorial correspondence for the Biochemical Journal (member of the Editorial Board, 1946-1950), Biochemical Pharmacology and Journal of Neurochemistry. There are also drafts for lectures and seminars for scientific audiences in the UK and abroad, principally from the 1960s onwards.

Section E, Societies and organisations, documents McIlwain's involvement with a number of UK and international bodies including the Biochemical Society, the International Brain Research Organisation and the International Society for Neurochemistry (ISN) of which he was a founder member and from 1984 'Historian' of the Society with responsibility for its archives.

Section F, Visits and conferences, covers the period 1947-1993 and is of particular interest for its documentation of the historical sessions which McIlwain organised at ISN meetings.

Section G, Correspondence, presents an alphabetical sequence of McIlwain's correspondence including significant exchanges with a number of distinguished mentors and contemporaries such as G.R. Clemo, F. Dickens, K.A.C. Elliott, P.G. Fildes, S.S. Kety, H.A. Krebs, Derek Richter and F.L. Rose, and a chronological sequence of shorter scientific correspondence covering the period 1938-1992.

There is also an index of correspondents.

Although the collection is by no means comprehensive, there are interesting records of many aspects of Wilson's career.

Section A. Biographical: Brings together material relating to obituaries, tributes, honours and awards. Includes Wilson's account of his First World War experiences and his assessment of his scientific publications. Section B. Research: Although not extensive, provides documentation of a number of Wilson's principal interests including the Salmonella group of bacteria and milk hygiene. There are three laboratory notebooks with experimental data covering the period 1919-45. Section C. Public Health Laboratory Service (PHLS): Relates chiefly to the unpublished history written by Wilson after his retirement as Director of the PHLS. There is also a little material relating to laboratory design and equipment and PHLS personnel. Section D. Lectures and publications: The most substantial in the collection. There are records of Wilson's lectures for a period of forty years from 1944, extensive documentation of the later editions of Principles of bacteriology and immunity, and editorial correspondence and papers for the British Journal of Experimental Pathology and the Journal of Hygiene. Section E. Societies and organisations: Documentation of Wilson's association with ten British organisations including the Medical Research Club, Medical Research Council and Veterinary Club. The Medical Research Council material relates to the Working Party on Tristan da Cunha which was set up to supervise medical investigations when the inhabitants were evacuated to Britain after the island's volcano erupted in 1961. There is also material relating to the Research Foundation, Chicago, which specialised in tuberculosis research, on whose medical advisory committee Wilson served. Section F. Visits and conferences: Records of a number of overseas trips in an advisory capacity for the World Health Organisation, including to Ethiopia 1964, Iraq 1965, Iran, Sudan and Egypt 1971 and the Philippines 1972, and records of international microbiology congresses. Section G. Correspondence: Although not extensive, includes a chronological sequence of scientific correspondence, 1930-1987, Wilson's collection of autograph letters addressed to Topley and himself, and references and recommendations. Section H. Photographs: Photographic records of Wilson, colleagues, conferences and PHLS laboratories. Section J. 'Biographical History of Bacteriology': Manuscript of Wilson's history, with correspondence about publication.