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Tottenham Court Manor was usually known as Tottenhall Manor. It was a prebendary held by clergymen at Saint Paul's Cathedral. The manor was leased out by the clergy until 1560 when it was demised to Queen Elizabeth. In 1639 it was leased to Charles the First, but was seized during the Civil War and sold. It was retaken on the Restoration, and in 1661 was granted to Sir Henry Wood by Charles the Second. The lease was taken over by Isabella Countess of Arlington, and inherited by her son Charles, Duke of Grafton and later by his brother the Honorable Charles Fitzroy, first Lord Southampton (descendants of Henry Fitzroy, Duke of Grafton, an illegitimate son of Charles the Second). In 1768 an act of Parliament vested the fee simple of the manor in Lord Southampton and his heirs, subject to an annual payment to the prebendary.
Part of the Tottenhall manor is now north-west Bloomsbury, while other parts of the manor stretched to Camden and St Pancras. Road names in this area reflect the family, such as Euston Road (Henry Fitzroy was also Earl of Euston) and Tottenham Court Road which is a corruption of Tottenhall.
Information from: 'Pancras', The Environs of London: volume 3: County of Middlesex (1795), pp. 342-382 and http://www.ucl.ac.uk/bloomsbury-project/streets/tottenham_court.htm.