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This hospital originated from the West Ham Board of Guardians Smallpox Hospital, which was established in Western Road , Plaistow in 1871, the Poplar Board of Works Infectious Diseases Hospital, which opened in Samson Street in 1878 and the Smallpox Hospital established in Pragel Street by West Ham Local Board in 1884. The Pragel Street premises closed in 1894 when the Samson Street premises were purchased by West Ham Borough Council and in the following year the Council likewise purchased the Smallpox Hospital at Western Road. Through the closure of part of Western Road, a large island site was made available for the development of a new Infectious Diseases Hospital, which opened in 1901 with accommodation for 210 patients as Plaistow Fever Hospital.
The new Hospital was considered to be one of the most modern of its kind and originated the barrier method of nursing infectious cases. Training of probationer nurses had commenced in 1898. In 1906 the Hospital was recognised by several universities and the royal college for the training of medical students in infectious diseases and over the next 37 years over 3000 students received fever training at Plaistow. The Hospital was damaged by bombing during World War II and in 1947 the older Samson Street buildings were made available for Queen Mary's Hospital, Stratford, as a medical in-patient department. The name of the Hospital was changed to Plaistow Hospital in 1948 in recognition of the fact that it was available for acute medical cases as well as infectious cases. In 1982 chest medicine beds were transferred to St. Andrew's Hospital by Newham Health Authority and from 1983 the hospital began to specialise in elderly long stay patients with such patients from Newham transferring from Langthorne Hospital, Leyton to Plaistow. A dementia assessment unit was opened in 1987and in 1990 Plaistow day Hospital was upgraded and extended to provide 40 places for elderly people. Management of the hospital transferred from East London & The City Health Authority to Newham Community Health Services NHS Trust in 1995. It closed in 2006 when the patients from the Frail Elders Services were transferred to the newly opened, purpose-built East Ham Care Centre, behind the East Ham Memorial Hospital in Shrewsbury Road. The patients had occupied just half the site of the Plaistow Hospital and it was felt it was no longer economically viable to keep the remaining staff on site.