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In 1994 a merger between The Royal London Hospital and Associated Community Services NHS Trust, St Bartholomew's Hospital and The London Chest Hospital resulted in the creation of The Royal Hospitals NHS Trust. In 1999 the Trust's name changed to Barts and The London NHS Trust. The Trust continued until a further merger with Whipps Cross University Hospital NHS Trust and Newham University Hospital NHS Trust in 2012. Management of the Queen Elizabeth Hospital for Children came under the Trust in 1995 and the hospital was formerly part of the Trust from April 1996 until the hospital's closure in 1998 whereupon services transferred to The Royal London Hospital.
The Trust initially came under the North East Thames Regional Health Authority and East London and The City District Health Authority more locally. From 1996-2002 it fell under NHS London Regional Health Authority and then North East London Strategic Health Authority until this was subsumed into NHS London Strategic Health Authority in 2006.