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The London Hospital Pathological Institute was built in 1901 as the Sir Andrew Clarke memorial. The first Director of the London Hospital Pathological Institute was Redcliffe Nathan Salaman (1874-1955), from 1904 to 1906. He was succeeded by Hubert Maitland Turnbull (1875-1955), Director of the Institute from 1906 to 1946. Post-mortem examinations, previously performed by one of four Physicians, were henceforth conducted either by Turnbull himself, or by one of his Assistants. The whole body was dissected, and exact measurements and specimens taken for microscopic examination.
In March 1909 the Institute initiated a Surgical Department, in which material from operating theatres and the Out-Patient Department was examined. In 1919 Dr Turnbull was awarded the title of Professor of Morbid Anatomy in the University of London. In 1927 the Institute was enlarged and opened by Regius Professor Sir Humphrey Rolleston as the "Bernhard Baron" Institute. Turnbull's successor was Professor Dorothy Stuart Russell (1895-1983), who was Director until 1960. From the 1960s onwards the Institute kept records for autopsies and histological examinations carried out for other hospitals: Bethnal Green, Mile End, London Chest Hospital and St. Andrew's Hospital. The Institute opened a Cytology Department for analysis of body fluids under Christopher Brown in 1966. After 1990 the Institute was known as The Royal London Hospital Pathological Institute. The Institute conducted post mortem and surgical department examinations for Bethnal Green and Mile End Hospitals from 1969 to 1978.