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In 1905, the Royal Orthopaedic Hospital amalgamated with the National Orthopaedic Hospital and became the Royal National Orthopaedic Hospital.
The original amalgamation was to have included the City Orthopaedic Hospital but this did not come about until 1907 when the City became part of the site at Great Portland and Bolsover Streets. In 1909 the Nurses' Home and Outpatients Department were opened and in July of that year the new hospital at Great Portland and Bolsover Streets was opened by Edward VII. The building was designed by Roland Plumbe.
During World War I, the hospital offered the War Office beds for military cases. In 1922 the 'country' branch of the hospital was opened at Brockley Hill, Stanmore and the buildings in the centre of London were known as the 'town' branch. There were 100 patients in 1923 and by 1927 the hospital was extended to meet increasing demand.
In 1923, the hospital opened the Royal National Orthopaedic Hospital School at the Stanmore site and in 1948 responsibility passed to Middlesex County Council and then the London Borough of Harrow in 1965 but the hospital's board of governors elected the governing body. The school provided full time education for children to the age of 16 and adult education from 1952. The school closed in 1998.
In the 1920s, proposals for amalgamation were received from the National Industrial Home for Crippled Boys based at Wrights Lane, Kensington. Amalgamation occurred in 1935 and the Stanmore Cripples Training College opened in 1937. Due to financial difficulties, it closed in 1949.
During World War II, the Great Portland Street basement was taken over by Marylebone Borough Council and the British Red Cross Society as a First Aid Post and Stanmore started to receive military patients in 1940. When V1 bombs started dropping in 1944, children from the hospital were evacuated, eventually returning in May, 1945.
In 1946, the Institute of Orthopaedics and Musculoskeletal Science was opened and moved to the Stanmore premises in 1948. The institute mainly conducts formal post graduate scientific research into orthopaedics and has close links with the University College of London (UCL).
In 1948, the hospital became an Independent Teaching Hospital and a Board of Governors replaced the Management Committee. In 1955, an Accident and Emergency Unit was opened at the Stanmore branch.
The Great Portland Street premises were closed in 1984. In 2008, the building at 49-51 Bolsover Street was sold for redevelopment and a new state of the art building was built at 45 Bolsover Street. This opened in December 2009 and called the London Outpatient Assessment Centre.
In 2011, approval was given for the complete redevelopment of the Stanmore Hospital which is scheduled for completion by 2014.