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The Saint Thomas' Hospital Group was formed in 1948 when the National Health Service was established by the National Health Service Act 1946. Originally it included only Saint Thomas' Hospital, the Grosvenor Hospital, the General Lying-In Hospital and the Royal Waterloo Hospital. However, the Lambeth Hospital became part of the Group in 1964 when the Lambeth Group Hospital Management Committee merged with the Wandsworth Hospital Management Committee to form the South West London Group Hospital Management Committee. In addition, the South Western Hospital moved to the Saint Thomas' Group in 1968, and the Royal Eye Hospital joined in about 1973.
In 1974, the National Health Service was re-organized into Area Health Authorities, split into Districts, rather than Groups. The Saint Thomas' Hospital Group became the Saint Thomas' Health District (Teaching) of the Lambeth, Southwark and Lewisham Area Health Authority, and now included Saint Thomas', Grosvenor, General Lying-In Hospital, Lambeth, Royal Waterloo and South Western Hospitals. These were joined in 1975 by Tooting Bec Hospital.
There was a further re-organization of the National Health Service in 1982, when the Saint Thomas' Health District (Teaching) became the West Lambeth Health Authority, now comprising Saint Thomas', General Lying-In, South Western and Tooting Bec Hospitals, with the addition of the Saint John's Hospital for Diseases of the Skin.
The final stage of reorganization occurred in 1993, when Saint Thomas' Hospital merged with Guy's Hospital to form the Guy's and Saint Thomas' Hospital Trust after the Tomlinson report of 1992 recommended that one of them be closed.