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The Small Pox Hospital was founded on Windmill Street, Tottenham Court Road in 1746, and was later moved to the parish of Saint Pancras on the site of the present King's Cross Station. The institution was rebuilt in c 1793-1794 when it received patients from the Cold Bath Fields Hospital in Clerkenwell, a foundation originating in Islington in 1740.
The hospital moved from King's Cross to Highgate Hill in c 1846, and from there to Clare Hall, South Minns c 1895-1899. It was acquired by the Middlesex Districts Joint Small Pox Hospital Board c 1900-1910. In May 1911, the Local Government Board made an order permitting the admission to Clare Hall of patients with pulmonary tuberculosis. Under a special order of the Minister of Health in 1928, the Hospital became a Middlesex County Council Institution. This came into effect on 1 April 1929 and the Joint Board was dissolved. In 1948 on creation of the National Health Service, the hospital was transferred to the North West Metropolitan Regional Hospital Board. In 1949 non-tuberculosis patients were admitted for treatment. The hospital was closed in 1975.