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The South West Middlesex Hospital Management Committee was formed in 1948 by the North West Metropolitan Regional Hospital Board to administer thirteen hospitals, which it took over from nine separate authorities: West Middlesex Hospital, Chiswick Maternity Hospital, Marrowells Maternity Annexe and Norwood Hall from the Middlesex County Council; Clayponds Hospital and Perivale Maternity Hospital from Brentford and Chiswick and Ealing Joint Hospital Committee; South Middlesex Hospital from the South Middlesex and Richmond Joint Hospital Board; and King Edward Memorial Hospital, Ealing, Teddington, Hampton Wick and District Memorial Hospital, Brentford Hospital, Saint John's Hospital, Twickenham, Saint Mary's Cottage Hospital, Hampton and Queen Victoria and War Memorial Hospital, Hanwell from six independent voluntary hospital committees.
Visitors from King Edward's Hospital Fund for London reported in May 1953 that the South West Middlesex Group was "the largest Group in London. Its expenditure is three times that of many groups. It is responsible for a large suburban area. It contains 12 hospitals which have varying backgrounds, ranging from the rugged independence of Queen Victoria Hospital, Hanwell to the colourless hospitals previously run by joint hospital boards The dead weight in the sense of material needs lies at the West Middlesex Hospital." The Hospital Management Committee was assisted by Finance, General Purposes, Establishment, Medical, and Nursing Sub-Committees. There was a Group Medical Advisory Committee as well as five House Committees dealing with several hospitals each.
The South West Middlesex Hospital Management Committee ceased to exist on 1 April 1974, when on the reorganisation of the National Health Service the hospitals in its care became the responsibility of Ealing, Hammersmith and Hounslow Area Health Authority.