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The office of Clerk is that of secretary to the Court and Chief Executive Officer of the Society. James Richard Upton held office 1872-1901, succeeding his uncle Robert Brotherson Upton. He died 8 December 1901 during a visit to India and a silver cup was presented to the Society in his memory. Archer Mowbray Upton held office 1901-1916, a solicitor like his father and great uncle, until he was dismissed from the Society's employment in 1916 for criminal proceedings against him. He was convicted of embezzling clients' funds from Upton and Co, Solicitors, the practice he held jointly with his brother. He was sentenced to three years' penal servitude and struck off the Roll of Solicitors. He had not, however, defrauded the Society.
Arthur Bingham Watson took up the post 16 May 1916 at a fixed salary of £300 per annum. He too was a solicitor and a partner in the firm Watson, Sons and Room. On 4 April 1917 Watson was admitted to the Freedom of the Society and was in office when the Prince of Wales, later Edward VIII, became the first ever Honorary Licentiate of the Society. He died 23 October 1927.
Philip Beaumont Frere was also a solicitor and held office 1928-1932. He was appointed 3 March 1928, having been admitted as a solicitor in 1920, and for thirty years was a senior partner in the firm of Frere, Chomley and Co of Lincoln's Inn Fields, established 1750. Frere was admitted to the Yeomanry of the Society in 1932 and promoted to the Livery in 1933. He was a member of the Grocers' Company and was elected to its Court in 1932, which is when he resigned his Clerkship. However he was then appointed solicitor to the Society. He became Master of the Grocers' Company, 1938-1939; it is probably unique for the former Clerk of one Livery Company to become Master of another. He was co-founder with Sir William Goodenough of the British United Provident Association, the foremost insurance company for private medical treatment. He retired from active practice in 1954.
Henry Cooper attained the rank of Colonel in all three armed services having already qualified as a doctor at the London Hospital in 1904. Cooper held office 1932-1941. He received the Distinguished Service Order and was appointed an Officer of the Order of the Crown of Belgium for notable conduct during World War One. Cooper retired from the services in 1932, having been previously appointed Principal Medical Officer of the Air Defences of Great Britain, Honorary Surgeon to the King, 1930-1932, and had been honoured as an Officer of the Order of St John of Jerusalem. Cooper was admitted to the Yeomanry of the Society in 1933 and the Livery in 1934. He also served in World War Two as Principal Medical Officer, Balloon Command, 1939-1942, and as Assistant Director of Personnel in the Emergency Medical Service, 1942-1945. He resigned the Clerkship in March 1941 and died in 1948.
Ernest Busby entered the Society's service in 1926 as Bursar. He was acting Clerk and Registrar from 1941 until December 1945, when he was confirmed as Clerk and Registrar. He became a member of the Livery in 1939. Busby was made Honorary Licentiate in Medicine and Surgery in 1967, during the celebrations for the 350th anniversary of the Society's Charter. He received an MBE. Busby retired in August 1977 after 50 years' service.