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Upton entered the East India Company's service as a midshipman in 1788 and served in the ROCKINGHAM during two voyages to China. He was in the GENERAL GODDARD as Fourth Officer on a voyage to Madras and Bengal from 1793 to 1794 and remained in her as part of the Cape Expedition of 1795. Nine Dutch Indiamen were captured during this cruise and Upton was detached in one of them as prize master. He went to China in the TRUE BRITON in 1804 and to Bengal in the WINDHAM in 1809, from which ship he was captured. However, after the taking of the Ile de France (Mauritius), Upton joined the CEYLON, 1810, and brought her home. His next voyage was to China, 1814, in the GLATTON; upon her arrival at St Helena her captain died and Upton was sworn in to command. Nothing further is known about his career.