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The Wood family settled at Littleton in Middlesex c 1663 and remained there until 1873/4, when the original mansion (built by Edward Wood 1663-5) was largely burnt down and Thomas Wood built a new one at Gwernyfed, Brecon, Wales. The present mansion was partially rebuilt on the same site by Richard Burbidge, who purchased the property from the Wood family.
A manuscript Pedigree Book of the Wood family was drawn up in the nineteenth century and this traces the family back to the fifteenth century, when they were living in Fulbourne, Cambridgeshire. Sir John Wood (1536-1633) sold the family estates in Fulbourne and settled in Beeston, Yorkshire, while his brother Nicholas settled in Norfolk.
Nicholas' son, Edward Wood, (c 1604-1667), was born in Suffolk and moved to London some time before 1634. The baptisms of several children are recorded in the registers of St. Dunstan's in the East, but only Thomas (1641-1723) survived infancy. Edward Wood described himself as a "Citizen and Grocer", and it seems that he had a house in Thames Street. He moved to Littleton around 1663 and set up as a gentleman farmer, while continuing to run his London business through his agent John Pack. Collection ACC/0262 includes many letters from Edward Wood to his agents discussing business matters.
Edward's son Thomas Wood married Dorothy Dicer in June 1666 at Saint Dunstan's in the East, and moved into the house at Littleton. Edward Wood died in March, 1667 and was buried at St. Dunstan's in the East on March 20th. Thomas and Dorothy had two sons, Robert and Edward, who both went to Eton and Oxford.
When Thomas died in 1723 Robert took over the Littleton house. He extended the family land holdings in the area, but it was his son, Thomas, who finally purchased the Manor of Littleton itself from Gilbert Lambell in 1749. It then remained in the hands of the Wood family until 1873.