The papers are very extensive though there are some lacunae, probably attributable to Chain's many changes of workplace. The early biographical period is sparsely documented, there are sporadic gaps in the correspondence files, and there is no original documentation of the penicillin research at Oxford (although there are many historical accounts and much correspondence about the history of penicillin). The surviving biographical material provides documentation of the arrangements for Chain to live and work in Britain, later honours and awards and his musical interests, and family correspondence, photographs and press-cuttings. There are very substantial records of his later career at the Istituto Superiore di Sanità and Imperial College, London, including his continuing contributions to biochemical problems such as carbohydrate metabolism, ergot alkaloids, edible proteins and aeration studies. The Imperial College material also contains records of the creation, administration, finance and architectural design of the Biochemistry Department, and developments in the Department after Chain's statutory retirement in 1973. Additional information about Chain's research is available in the documentation of his very extensive consultancy agreements and collaborative work with industrial firms such as Astra, Beechams and Rank Hovis McDougall, and records relating to government, grant-giving and charitable bodies such as the British Heart Foundation, Cancer Research Campaign and Medical Research Council which contributed to the funding of his research. There is much material on Chain's lectures, addresses and broadcasts, and on his extensive travel on visits and conferences, which includes a substantial number of unpublished talks.

An exceptional feature of the Chain papers is the documentation of the large number of Israel and Jewish organisations with which he was associated, especially the Weizmann Institute of Science, where he was a governor for many years and had at one time considered taking up an appointment.

Records, 1926-1951, of the Chinese Government Purchasing Commission (CGPC), including information on the state of Chinese communications; the workings of the Chinese Ministries of Communications, Railways and Industries; Chinese banking; construction and engineering technology and the work of British manufacturers; and some information on Chinese educational and cultural institutions in receipt of subsidies from the Board of Trustees for the Administration of the Indemnity Funds Remitted by the British Government.

Records, 1926-1951, relating to the foundation and constitution of the CGPC comprise printed report of the Anglo-Chinese Advisory Committee (China Indemnity Advisory Committee), 1926; correspondence, largely letters from the Board of Trustees to the CPGC, 1931-1950, concerning the constitution of the Commission, procedural issues, personnel and financial matters; file on procedure on appointment of a new member of the Commission, 1947-1948; correspondence concerning events preceding the winding-up of the Commission, 1951.

Financial records, 1931-1951, comprise papers on the Board Account, 1937-1950; papers on the Chin Fund (apparently a grant paid to Constance Chin, a patient of the Bethlem Royal Hospital), 1945-1951; summaries of expenses relating to purchase orders made by Chinese ministries, 1931-1951; Indemnity Fund cash books, 1937-1950; invoices and receipts relating to CGPC business, 1937-1951; financial statements and correspondence relating to banking matters with the Hong Kong and Shanghai Bank, 1931-1951, the subjects including investments and tax.

Operational records, c1928-1951, relating to the administration of purchase orders, comprise register of tenders/purchase orders, 1942-1946; contract registers (not comprehensive), 1931-1949, recording the management of contracts for the supply and delivery in China of plant, machinery and other materials manufactured in the UK for the Chinese government, and over 1,000 related contract files for engineering companies and manufacturers for industrial, construction, railway and other projects; tender forms, 1934, issued to contractors by the CGPC; specifications and standards, c1928-1937 and undated, largely for the construction of railways and carriages; correspondence concerning administration of purchase orders, 1932-1951, relating especially to delivery of locomotive spare parts and related materials; registers of export licences issue to British manufacturers under wartime regulations, 1941-1946; applications for export licences, 1939-1945; registers of shipments, insurance, freight and inspection fees, 1931-1951; shipping letters, 1937-1950, issued for CGPC shipments; general correspondence concerning the administration of the CGPC, 1931-1951, including correspondence with solicitors and correspondence concerning the CGPC premises in Tothill Street, London.

Annual reports and accounts, 1931-1950, comprise typescript accounts and reports, 1931-1950, of the CGPC and published annual reports, 1931-1950, including summaries of receipts and payments; and annual reports of the Board of Trustees, 1931-1938.

Miscellaneous records, c1932-1950, comprise one file including papers on subjects including railways, training Chinese students, Japanese imperialism, and CGPC records, a photograph of ships in harbour, and maps of China and the Far East.

Records, 1939-1943, of the China Purchasing Agency Ltd comprise standing regulations of the Board of Directors, undated; correspondence, 1939-1943, concerning various purchase orders; miscellaneous items, c1939-1940, including list of tenders passed for acceptance, 1939, and an undated schedule of materials shipped.

Working papers and correspondence of Sir Francis (Franz) Eugene Simon. Scientific notebooks in the collection date from 1919-1934, largely the period of Simon's researches on low temperature physics at the Physikalisch-Chemisches Institut of Berlin University, and subsequently at Breslau. Other notes and manuscripts for lectures and articles are post 1930, while a large group of correspondence files are from the years 1922-1956, providing a full account of Simon's dealings with many fellow scientists and scientific organisations. Individual letter files concern V.M. Goldsmidt, Max Born, Gwyn Owain Jones and Nevill Mott among many other notable figures. Details of Simon's involvement in atomic energy development are to be found in papers on uranium isotope separation (MAUD Committee notes) and UK Atomic Energy Authority correspondence. Simon's professional appointments as head of the Clarendon Laboratory and as science correspondent to the Financial Times are represented by substantial groups of letters. There are twelve notebooks with some associated papers; the series also includes files of lectures, articles, cuttings and souvenirs, including photographs, with files of correspondence. Two later additions to the collection consist of correspondence and files highlighting Simon's contacts with industrial firms, universities and international organisations.