The archive spans Browne's career from school onwards, but the core series of records focus on his work as a medical missionary at the BMS hospital in Yakusu, Belgian Congo (now the Democratic Republic of Congo). Section B comprises records for the period 1938-1958, including registers of leprosy sufferers, case records and photograph albums documenting various symptoms. Section K contains further photographs (mainly clinical) for the period 1938-1977, the most important series of which dates from Browne's time at the Baptist Mission Hospital and comprises over 900 negatives and prints together with supporting documentation, 1954-1958.
Section C contains a small number of files compiled by Browne during his research into leprosy, yaws, onchocerciasis and ainhum, 1946-1983. Particularly notable are the files on the anti-leprosy drug B663 (now known as clofazimine), into the use of which Browne conducted pioneering studies whilst director of the Leprosy Research Unit, Uzuakoli, Eastern Nigeria, 1959-1966.The remaining records comprise personal and biographical material, 1923-1985 (section A); general subject files containing correspondence, reprints etc. on a wide variety of topics, 1948-1986 (section D); writings by Browne, 1935-1985 (section E); records of Browne's involvement with the International Leprosy Association, 1909-1985 (section F) and various other organisations, 1959-1986 (section G); records on foreign visits, 1965-1985 (section H); and a few files on religious matters, 1959-1984 (section J).